Senior Scientist - Drug Product Development

arcusbiosciencescareers; Hayward (CA); On-site; USD 150,000 - 165,000; Full time

Benefits offered by this job

Stock programs

Performance-based bonus

Comprehensive benefits package

Job summary

Arcus Biosciences is seeking a Sr. Scientist in Hayward, CA, to provide hands-on formulation expertise for solid oral dosage forms. The ideal candidate will have a MS/PhD in Pharmaceutical Sciences with 4+ years (PhD) or 7+ years (MS) experience in the pharmaceutical industry. Responsibilities include developing formulations, collaborating with Manufacturing partners, and ensuring compliance with regulatory standards.

The role offers a competitive salary of $150,000 – $165,000 and benefits including participation in stock programs and performance-based bonuses.

Qualifications

• 4+ years experience for PhD or 7+ years for MS in pharmaceutical industry.
• In-depth understanding of manufacturing unit operations like granulation and milling.
• Experience in scale-up studies using QbD approach.

Responsibilities

• Develop clinical and commercial formulations for solid oral dosage forms.
• Perform high-level risk assessment and prepare technical reports.
• Work with external CMOs for process transfer.

Skills

Hands-on formulation expertise

Analytical skills

Communication skills

Creative thinking

Detail-oriented

Education

MS or PhD in Pharmaceutical Sciences or related field

Tools

High-Pressure Liquid Chromatography (HPLC)

Differential Scanning Calorimetry (DSC)

Thermogravimetric Analysis (TGA)

X-ray Powder Diffraction (XRPD)

Job description

Summary

Sr. Scientist will provide hands‑on formulation and process expertise primarily in solid oral formulation related activities and present scientific data in the drug product development function.

Responsibilities

• Provide hands‑on formulation and process expertise to develop clinical and commercial formulations for the solid oral dosage forms.
• Accountable for drug product process development and related analytical activities.
• Design and execute formulation experiments, organize and analyze results with minimal direction, and communicate and present in team meetings.
• Perform high-level risk assessment/failure modes and effects analysis for the manufacturing process and prepare technical reports.
• Work with external manufacturing CMOs to enable the transfer and implementation of processes and assist in the root cause analysis (RCA) process.
• Under the guidance of the Director of Drug Product Development, help implement and maintain a state‑of‑the‑art drug product development laboratory.
• Interact effectively & build successful relationships with members of the drug product group and other Arcus stakeholders (Drug Substance, Quality, Analytical Development, Regulatory, Medicinal Chemistry, Clinical Operations & Discovery Biology).

Qualifications

• MS or PhD in Pharmaceutical Sciences, Material Sciences, Chemistry, Chemical Engineering, or other relevant fields of study.
• 4+ years of experience for PhD and 7+ years of experience for MS candidates in the pharmaceutical industry, emphasizing oral solid dosage forms with an in‑depth understanding of typical manufacturing unit operations such as granulation, roller compaction, drying, milling, blending, compression/encapsulation, film coating, and spray drying, etc.
• Experience in scale‑up studies using the QbD approach and principles.
• Experience interacting with Contract Research/Manufacturing Organizations.
• Experienced in oral formulation development, drug product process development, and technology transfer. Experience with parenteral formulation will be a plus.
• Experienced in High‑Pressure Liquid Chromatography (HPLC) as an analytical tool for evaluating formulation stability.
• Experience with DSC, TGA, XRPD, and other advanced formulation scientific equipment.
• Strong interpersonal skills: ability to communicate effectively both verbally and in written formats to collaborate effectively with the rest of the Drug Product Development team and well as across other teams.
• Detail‑oriented, rigorous, and excellent skills in record keeping/documentation.
• Proven ability to think creatively, learn new technologies, and obtain solutions to complex and diverse problems.

Compensation & Benefits

Location: Hayward, CA.

Salary range: $150,000 – $165,000 USD annually for fully qualified candidates.

In addition to a competitive market‑based salary, Arcus offers the opportunity to participate in stock programs, a performance-based bonus, and a comprehensive benefits package. Additional information about our total rewards program can be found at https://arcusbio.com/careers.

Equal Opportunity Employer

Arcus Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Arcus is committed to the principle of equal employment opportunity for all employees and does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, non‑disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets

Physical Requirements

Must possess mobility to work in a standard office setting and use standard office equipment, including a computer; vision to read printed materials and a computer screen; and hearing and speech to communicate in person, before groups, and over the telephone. This is primarily a sedentary office classification although standing in work areas and walking between work areas may be required. Finger dexterity is needed to access, enter, and retrieve data using a computer keyboard, mouse, or calculator, and to operate standard office equipment. Positions in this classification occasionally bend, stoop, kneel, reach, push, and pull drawers open and closed to retrieve and file information. Employees must possess the ability to lift, carry, push, and pull materials and objects weighing up to 25 pounds.