Senior Scientist, Bioproduction and Bioprocessing

SeQure DX; Rockville (MD); On-site; USD 140,000 - 230,000; Full time

Benefits offered by this job

Base salary + annual bonus + equity

Comprehensive benefits package

Job summary

SeQure DX is seeking a Senior Scientist, Bioproduction & Bioprocessing to lead mammalian cell-based production developments for research and manufacturing needs. You will guide stable cell line generation, transient expression, and upstream processing while collaborating with cross-functional teams to ensure quality and timely delivery.

The role emphasizes data analysis, process improvement, and scientific innovation, with opportunities to advance production strategies and platform capabilities.

Qualifications

• PhD in biological sciences or related field with 10+ years in bioproduction or cell line development.
• Expertise in stable cell line development and clone selection.
• Extensive hands-on experience with transient expression of antibodies or recombinant proteins.
• Strong foundation in mammalian cell culture and upstream protein expression.
• Experience with high-throughput screening, automation, or analytical tools.
• Background in vector design, media/feed optimization, or bioprocess development.
• Experience in milestone-driven industry or core lab environments.

Responsibilities

• Lead workflows for stable pool and stable cell line generation, including transfection and clone screening.
• Perform stable pool and transient experiments using relevant CHO and HEK cell lines.
• Develop and optimize transient protein expression processes for antibodies and proteins.
• Conduct upstream studies and prepare materials for scale-up.
• Design, execute, and troubleshoot experiments per protocols and quality standards.
• Analyze data, prepare technical summaries, and present results to stakeholders.
• Collaborate with downstream, analytical, and project management teams to ensure timely delivery.
• Provide scientific support to customer-facing teams with remote and onsite troubleshooting.
• Identify improvements to bioproduction workflows, media/feed optimization, and vector enhancements.
• Evaluate new technologies and automation tools to increase efficiency and scale.
• Lead exploratory studies and integrate validated improvements into workflows.
• Contribute to internal innovation and long-term bioproduction strategy.
• Maintain accurate, complete, and compliant laboratory records.

Skills

Stable cell line development

Clone selection

Transient expression

Mammalian cell culture

High-throughput screening

Automation

Vector design

Media optimization

Education

PhD in biological sciences

Master’s + 13+ years experience in bioproduction

Job description

Job Type

Full-time

Description

The Senior Scientist, Bioproduction & Bioprocessing is responsible for leading the development, optimization, and execution of mammalian cell-based protein production workflows to support organizational research, development, and manufacturing needs. This role provides subject-matter expertise in cell line development, transient expression, and upstream bioprocessing, and ensures high-quality delivery of materials through collaboration with cross-functional teams. The Senior Scientist contributes to scientific innovation, process improvement, and customer support activities.

• Lead and execute workflows for stable pool and stable cell line generation, including transfection, clone screening, productivity assessment, and documentation.
• Perform stable pool and transient experiments using CHOZN, CHOK1-sv, CHOK, HEK293, and other protein production-relevant cell lines.
• Develop, optimize, and scale transient protein expression processes for antibodies and recombinant proteins.
• Conduct upstream protein expression studies, including small-scale evaluations and preparation for scale-up.
• Design, perform, and troubleshoot laboratory experiments in accordance with established protocols, quality standards, and regulatory expectations.
• Analyze experimental data, prepare technical summaries, and present results to internal and external stakeholders.
• Collaborate with downstream purification, analytical development, and project management teams to ensure alignment and timely delivery of materials.
• Provide scientific support to customer-facing teams, including remote and onsite troubleshooting with Field Application Scientists.
• Identify opportunities to enhance bioproduction workflows, including media/feed optimization, vector improvements, and process parameter refinement.
• Evaluate and implement new technologies, automation tools, and high-throughput approaches to increase efficiency and scalability.
• Lead exploratory studies to assess emerging bioprocessing methods and integrate validated improvements into standard workflows.
• Contribute to internal innovation initiatives, including development of new production strategies, platform enhancements, and scientific capability expansion.
• Provide technical insight to support long-term bioproduction strategy and organizational growth.
• Maintain accurate, complete, and compliant laboratory records.
• Ensure adherence to organizational, regulatory, and safety standards.

Requirements

• PhD in biological sciences or related field with 10+ years of relevant industry experience (or Master’s degree with 13+ years of experience) in bioproduction, bioprocessing, or cell line development
• Demonstrated expertise in stable cell line development and clone selection.
• Extensive hands-on experience with transient expression of antibodies or recombinant proteins.
• Strong foundation in mammalian cell culture and upstream protein expression.
• Experience with high-throughput screening, automation, or advanced analytical tools.
• Background in cell engineering, vector design, media/feed optimization, or bioprocess development.
• Prior experience in structured, milestone-driven industry or core laboratory environments.
• Good communication skills and ability to work collaboratively with internal team members and customers
• Ability to travel up to 20%

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status