Senior Scientist, Bioinformatics

AstraZeneca GmbH; Waltham (MA); On-site; USD 116,000 - 174,000; Full time

Job summary

AstraZeneca's QuBi team in Cambridge, MA seeks a Senior Scientist, Bioinformatics - Proteomics to design and implement MS-based proteomics analyses, build data platforms, and deliver robust workflows for high-throughput data.

The role combines proteomics expertise with bioinformatics, data science, and AI-enabled workflow development, collaborating across multidisciplinary teams to advance digital capabilities.

Qualifications

• PhD in bioinformatics, computational biology, proteomics, biostatistics, data science, computer science, or equivalent.
• Solid grounding in the statistics of high-dimensional omics data.
• Experience with bioinformatics data analysis and reproducible workflows.
• Experience with cloud platforms (AWS or Azure).
• Experience designing scalable omics data models and applying FAIR data principles.
• Experience in programming with R and/or Python; familiarity with scientific software development best practices.
• Experience building reproducible workflows with Nextflow or Snakemake and containers in Linux.
• Proficiency with Git/GitHub and collaborative software development practices.
• Ability to work independently while collaborating across multidisciplinary teams.
• Strong communication skills to explain complex concepts and support adoption.

Responsibilities

• Workflow development and automation: design, implement, and maintain end-to-end MS-based proteomics analysis pipelines (DDA and DIA; label-free, TMT/iTRAQ, SILAC).
• Wrap and orchestrate tools into portable, versioned workflows using Nextflow or Snakemake.
• Develop tools and workflows with interfaces, metadata, and execution standards for AI-enabled systems.
• Containerize tool environments (Docker, Kubernetes) and deploy pipelines to HPC (Slurm) and/or cloud compute.
• Establish software engineering practices for the group — version control, code review, unit and regression testing, CI/CD, documentation, and release management.
• Data management: design and maintain a proteomics data model and storage strategy for raw files, intermediate results, processed matrices, and provenance.
• Apply FAIR principles and data governance with IT/security.
• Build searchable result databases (Snowflake/PostgreSQL) and interfaces (R Shiny or Streamlit).
• Analysis and scientific collaboration: perform proteomics analyses integrating chemical biology and metadata to generate biological insight.
• Support study design, data interpretation, quality assessment, and development of scalable analytical methods including AI-enabled approaches.

Skills

PhD in bioinformatics/computational bi

Statistics of high-dimensional omics

Cloud platforms (AWS/Azure)

R and/or Python programming

Nextflow or Snakemake workflows

Docker/Kubernetes containers

Git/GitHub version control

Independent scientific contributor

Communication of complex concepts

Education

PhD in bioinformatics, computational biology, proteomics, biostatistics, data science, CS

Tools

Nextflow

Snakemake

Docker

Kubernetes

AWS

Azure

Git/GitHub

Snowflake

PostgreSQL

R

Python

Job description

Make a meaningful impact on patients’ lives around the world

At AstraZeneca, we are combining cutting-edge science, data, and artificial intelligence to transform how we discover and develop medicines. As part of Data Sciences and Quantitative Biology (QuBi) this role will work in close collaboration with a group of chemical biology and proteomics scientists supporting therapeutic areas across AstraZeneca, offering a unique opportunity to contribute to and apply new digital and AI capabilities.

Based at our new Kendall Square site in Cambridge, Massachusetts, you will work at the intersection of mass spectrometry-based (MS) proteomics and computational biology, helping to build the data platform and analytical foundations that allow scientists to explore high-throughput proteomics and emerging molecular assays. This is a hands-on scientific and technical role for someone who combines strong proteomics expertise with practical bioinformatics, data science, and workflow development skills to deliver robust analyses, workflows, and tools that scientific teams can rely on.

What you will do

As Senior Scientist, Bioinformatics - Proteomics within QuBi, you will:

• Workflow development and automation

• Design, implement, and maintain end-to-end MS-based proteomics analysis pipelines (DDA and DIA; label-free, TMT/iTRAQ, SILAC) for the processing, analysis, interpretation, and visualization of high-throughput proteomics data.
• Wrap and orchestrate tools into portable, versioned workflows using Nextflow or Snakemake.
• Develop tools and workflows with the interfaces, metadata, and execution standards needed to support reuse by emerging agentic and AI-enabled systems.
• Containerize tool environments (Docker, Kubernetes) and deploy pipelines to HPC (Slurm) and/or cloud compute.
• Establish software engineering practices for the group — version control, code review, unit and regression testing, CI/CD, documentation, and release management.

• Data management and infrastructure

• Design and maintain a proteomics data model and storage strategy for raw files, intermediate results, processed matrices, and analysis provenance.
• Apply FAIR principles and appropriate data governance, access control, and retention policies in collaboration with IT/security.
• Build searchable result databases (using Snowflake/PostgreSQL) and interfaces (using R Shiny, or Streamlit).

• Analysis and scientific collaboration

• Perform proteomics analyses integrating chemical biology and experimental metadata to generate biological insight.

• Apply domain expertise in MS-based proteomics to support study design, data interpretation, quality assessment, and biological insight generation, particularly in support of chemical biology applications.
• Contribute to the development of scalable analytical methods and digital capabilities, including AI-enabled and agentic approaches, to support scientific discovery and decision-making.

Required qualifications

• PhD in bioinformatics, computational biology, proteomics, biostatistics, data science, computer science, or a related discipline, or equivalent research experience.
• Solid grounding in the statistics of high-dimensional omics data
• Demonstrated experience in bioinformatics and data analysis, with the ability to develop and apply reproducible analytical workflows for complex biological datasets.
• Experience with cloud platforms (such as AWS or Azure), covering core concepts like virtual machines, storage buckets, and basic cloud networking.
• Experienced in designing scalable omics data models and in applying FAIR data principles and data governance.

• Experience with programming and data analysis in languages such as R and/or Python, and familiarity with scientific software development best practices.
• Experience in building reproducible workflows with a pipeline framework (Nextflow, Snakemake) and containers in Linux environment.
• Proficiency with version control (Git/GitHub) and collaborative software development practices.
• Ability to work as an independent scientific contributor while collaborating effectively across multidisciplinary teams.
• Strong communication skills, with the ability to explain complex scientific and technical concepts to diverse audiences and support adoption of analytical solutions.

Preferred qualifications

• Demonstrated experience analyzing MS-based discovery proteomics data, with practical command of at least one major search/quantification platform (FragPipe, DIA-NN, Spectronaut, Proteome Discoverer, or equivalent).

• Experience developing or applying machine learning and AI for scientific data analysis, interpretation, or workflow automation.
• Experience in multi-omics analysis is a plus

• A track record of scientific innovation demonstrated through publications, conference presentations, open-source contributions, software products, or deployed analytical tools in bioinformatics, AI, or data science.

How we do it

At AstraZeneca,we'rededicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.There'sno better place to make a difference in medicine, patients, and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth, and development.

The annual base salary for this position ranges from $116,284.00 to $174,426.00. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Closing Date: 30-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.