Senior Scientist, Bioanalytical Sciences – Translational

Addition Therapeutics; South San Francisco (CA); On-site; USD 110,000 - 130,000; Full time

Benefits offered by this job

Equal opportunity employer

Job summary

Addition Therapeutics is seeking a dynamic Scientist/Senior Scientist to join the Bioanalytical Sciences team in South San Francisco. The role focuses on designing and executing in vitro, cell-based, and ex vivo assays to evaluate PRINT™-delivered payloads and assess pharmacology for preclinical translation.

You will contribute to translational studies across obesity and metabolic disease programs and collaborate across therapeutic technology development, pharmaceutical sciences, and preclinical

Qualifications

• PhD in molecular biology, biochemistry, pharmacology, cell biology, or a closely related field (relevant industry experience considered in lieu of Ph.D.)
• Proficiency across standard molecular/biochemical assay platforms: ELISA, MSD, AlphaLISA, ddPCR, qPCR, Western blot, flow cytometry, and microscopy
• Experience in mammalian cell culture to support cell-based assays
• Ability to independently design experiments, troubleshoot, and interpret data
• Clear and organized scientific communicator, comfortable presenting data to cross-functional audiences

Responsibilities

• Design, develop, validate, and execute in vitro, cell-based, and ex vivo assays to evaluate efficacy, pharmacology, and delivery of payloads using PRINT technology
• Develop and execute pharmacodynamic assays to measure transgene expression, protein production and secretion, enzymatic activity, receptor engagement, and downstream biological responses
• Develop and run cell-based functional assays to evaluate therapeutic efficacy across obesity and other metabolic diseases
• Establish assays using primary cells, immortalized cell lines, and tissue-derived samples to support translational studies
• Collaborate with in vivo pharmacology teams to analyze plasma and tissue samples from rodent and non-human primate studies
• Ensure accurate and reliable results through meticulous hands-on execution and record-keeping
• Support PK/PD characterization by generating quantitative bioanalytical data to inform dose selection and mechanism of action
• Contribute to assay transfer, qualification, documentation, and implementation of best laboratory practices
• Collaborate with internal teams and partners to integrate and optimize current and new assay technologies and methodologies
• Analyze experimental data, interpret results, and present findings in team meetings
• Stay up to date with relevant scientific literature and emerging technologies
• Provide input on potential improvements or innovations in assay development and genomic medicine applications
• Contribute to data packages supporting IND-enabling studies, partnership diligence, and investor milestones

Skills

Molecular biology

Biochemistry

Pharmacology

Mammalian cell culture

Assay design & execution

ELISA

MSD/AlphaLISA

ddPCR/qPCR

Western blot/Flow cytometry

Microscopy

Education

PhD in molecular biology or related field

Tools

HTS

Automated liquid handling

qPCR machines

Job description

Addition Therapeutics is seeking a dynamic Scientist/Senior Scientist to join the Bioanalytical Sciences team in South San Francisco. The role focuses on designing and executing in vitro, cell-based, and ex vivo assays to evaluate PRINT™-delivered payloads and assess pharmacology for preclinical translation.

You will contribute to translational studies across obesity and metabolic disease programs and collaborate across therapeutic technology development, pharmaceutical sciences, and preclinical