Senior Scientist, Antibody Repertoire Sequencing & Discovery

BioSpace; Worcester (MA); On-site; USD 130,000 - 180,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision

401(k)

Job summary

AbbVie Bioresearch Center in Worcester, MA is seeking a Senior Scientist to join the Molecular Core. You will lead antibody repertoire sequencing efforts (RepSeq/AIRR-Seq/BCR-Seq) to enable therapeutic antibody discovery and hit expansion.

You will work with computational scientists to optimize repertoire analysis and advance ML-driven antibody discovery. Responsibilities include data generation, documentation, and presentation to cross-functional teams; you will be part of a fast-paced,

Qualifications

• PhD/MS/BS with 0-12+ years experience in relevant fields
• Expertise in immunoglobulin genetics and antibody biology
• Experience with antibody variable region gene isolation for NGS
• Familiar with Illumina NextSeq/MiSeq and PacBio platforms
• Proficiency with molecular biology techniques (PCR, cloning, Gibson Assembly)
• Ability to improve processes and document rigorously
• Strong communication in cross-functional teams

Responsibilities

• Lead antibody repertoire sequencing efforts (RepSeq/AIRR-Seq/BCR-Seq) for discovery and hit expansion
• Collaborate with computational scientists to optimize repertoire analysis
• Generate, document, and archive repertoire data with context and metadata
• Analyze and interpret results and present findings to team
• Coordinate work within a matrixed project team
• Demonstrate scientific excellence across multiple projects
• Communicate effectively across functional teams

Skills

Immunology expertise

Antibody biology

B cell biology

RepSeq knowledge

Computational science

AI/ML familiarity

Data analysis

Education

BS/MS/PhD in immunology or related field

Tools

PipeBio

Geneious

Sequencher

Illumina

PacBio

PCR

Gibson Assembly

Molecular cloning

Job description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivatedSeniorScientist to join theMolecularCoreteam at AbbVie Bioresearch Center (ABC). The ABC site in Worcester, MA, offersaunique setting where Biotherapeuticsdiscovery, development and manufacturing coexist in one location.TheMolecular Corepartnerswith multidisciplinary groups across AbbVie focused on developing therapies for Immunology, Neurology and Oncology diseases.We utilize innovative approaches for antibody discovery including in vivo technologies, custom immunization strategies, advanced multiplex screening assays and best-in-class automation platforms to enable successful antibody discovery against complex targets.

Responsibilities

• Act as scientificand technicalexpert inantibodyrepertoire sequencing (RepSeq/AIRR-Seq/BCR-Seq) fortherapeuticantibody discoveryand hit expansionBulk sequencing, 10X,and other commercial and proprietary platforms.
• Collaborate withcomputationalscientists to optimizerepertoireanalysis and open new avenues forantibodydiscoverythrough repertoire guided machine learning andgenerative design
• Generate, document, and archive repertoire data with appropriate context and metadata to support broader team access andfutureutilization.
• Analyze and interpret results, placing data in proper scientific context through review of relevant literature, and present findings at team meetings.
• Regularly present data, communicate effectively, and coordinate work within a highly matrixed project team environment.
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced, multidisciplinary environment.
• Exhibit a can-do attitude and strong interpersonal and communication skills when working across multiple functional teams.

Qualifications

• BS, MS, or PhDinimmunology,molecularbiology,biochemistry,bioinformaticsor a related fieldwith typically0-4+ (PhD), 8-10+ (MS), or 10-12+ (BS) yearsofrelevant experience
• Extensive scientific expertisein immunoglobulin genetics and antibody biology;specifically,the candidate should be well versed inantibody diversity generation (germline genes/V(D)J recombination/somatic hypermutation), affinity maturation, andB cell biology.
• Extensive technical expertiseintheisolation and molecular biology of antibody variable region genes for Next-generation Sequencing (NGS)and the capture of RepSeq/AIRR-Seq/BCR-Seq)data; both for single-chain and paired heavy- and light-chain recovery
• Understanding ofNGS technologiesand platforms Illumina (NextSeq, MiSeq)andPacBio
• Understanding and proficiency in molecular biology techniques (e.g. PCR,primer design,molecular cloning, Gibson Assembly, plasmid design)
• Ability to improve and streamline existing processes
• Strong attention to quality and details when exercising organizational, documentation and communication skills
• Proven flexibility to deal with changing timelines and shifting work priorities
• Competency with software programs, includingantibody analysis (PipeBio),DNA analysis (Geneious, Sequencher) and MS Office(Excel, PowerPoint, Word)
• Fluency incomputational science and familiarity withthe application ofpredictiveAI/MLtoolsand protein language models (PLMs)forantibodydiscovery

Desirable

• Experience in non-human and non-murine immunogenetics
• Prior experiencewithbioinformaticsand computationalanalysis of large DNA and proteindata setsis highly desired
• Experience with repertoire sequencing fromin vitroantibody discovery libraries
• Experience with mammalian cell culture, aseptic technique, and transient transfection
• Experience in immunoassays using techniques like ELISA and flow cytometry

Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II

Additional Information

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprogram.
• This job may be eligible toparticipatein our long-term incentiveprogram.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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