Senior Scientist

Pfizer, S.A. de C.V; Cambridge (MA); On-site; USD 94,000 - 156,000; Full time

Benefits offered by this job

401(k) with Pfizer matching

Performance bonus (12.5% target)

Comprehensive benefits

Job summary

Pfizer Cambridge, MA is seeking a Senior Scientist to drive drug discovery in the Cardiovascular Discovery Biology team. You will contribute to hypothesis generation, target validation, and biomarker development, collaborating across disciplines to advance atherosclerosis-related programs.

We value strong experimental strategy, independence, and clear scientific communication. Expertise in cardiovascular biology, in vitro/in vivo models, and data interpretation will help accelerate portfolio

Qualifications

• Ph.D. in Molecular Biology, Biotechnology, cardiovascular biology, or related field.
• 1–2 years postdoc or industry experience in drug discovery or translational research.
• Demonstrated cardiovascular or atherosclerosis disease biology expertise.
• Proficiency with in vitro and in vivo cardiovascular-atherosclerotic systems.
• Strong analytical and problem-solving abilities with independent yet collaborative work.

Responsibilities

• Develop strategies to identify and validate therapeutic targets aligned with IMRU priorities.
• Investigate mechanisms of atherosclerotic plaque progression using cellular, molecular, and animal models.
• Stay current with preclinical and translational science advances and apply them to portfolio programs.
• Build collaborations with academic partners and Pfizer scientists.
• Communicate findings through publications, presentations, and internal briefings.
• Uphold scientific integrity, quality, and regulatory/ethical guidelines.
• Mentor junior scientists and support collaborative engagement.

Skills

Cardiovascular biology

Atherosclerosis biology

In vitro & in vivo models

Molecular biology

Data analysis

Scientific communication

Team collaboration

Education

Ph.D. in Molecular Biology

Tools

High-content imaging

In vivo models

Job description

• United States - Massachusetts - Cambridge

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

At Pfizer, our purpose is to deliver breakthroughs that transform patients’ lives. Central to this mission is our Research and Development organization, which is dedicated to translating advanced science and innovative technologies into impactful therapies and vaccines. In this role, you will be at the forefront of this effort, helping ensure that daily activities align with Pfizer’s unwavering commitment to quality. Your work will accelerate the delivery of best-in-class medicines to patients globally and support Pfizer’s commitment to making a meaningful difference in healthcare.

ROLE SUMMARY

As a member of the Cardiovascular Discovery Biology team, the Senior Scientist will play a pivotal role in the drug discovery process, from ideation and hypothesis generation to the identification and validation of therapeutic targets and disease-relevant biomarkers.

This individual will contribute to experimental strategy and execution while working closely with scientists across disciplines. Expertise in atherosclerosis biology is essential, and familiarity with different aspects of cardiovascular disease is highly desirable. Daily interactions will take place within a dynamic and supportive environment of innovative scientists. Success in this role requires strong self-motivation, excellent communication and interpersonal skills, and the ability to influence and collaborate effectively in a team setting.

ROLE RESPONSIBILITIES

• Apply scientific expertise and creative thinking to develop strategies for identifying and validating therapeutic targets aligned with IMRU priorities.
• Apply state-of-the-art cellular, molecular, and animal model techniques to investigate mechanisms of atherosclerotic plaque progression, including data analysis and interpretation.
• Stay current with cutting-edge developments in preclinical and translational science and integrate relevant advances into portfolio programs.
• Build and maintain collaborations with academic partners and internal Pfizer scientists.
• Communicate research findings through peer-reviewed publications, scientific presentations, and internal leadership briefings.
• Uphold the highest standards of scientific integrity, quality, and compliance with regulatory and ethical guidelines.
• Support the development of junior scientists through mentorship and collaborative engagement.

QUALIFICATIONS

Basic Qualifications:

• Ph.D. in Molecular Biology, Biotechnology, Cardiovascular Biology, or related fields.
• A minimum of 1–2 years of postdoctoral or relevant industry experience in drug discovery or translational research.
• Demonstrated expertise in cardiovascular or atherosclerosis disease biology.
• Proficiency in vitro and in vivo cardiovascular-atherosclerotic systems, including foam-cell and vascular-cell assays, molecular biology, high-content imaging, ex vivo approaches, and rodent models of atherosclerosis.
• Strong analytical and problem-solving capabilities, supported by a track record of impactful scientific contributions.
• Proven ability to work independently and collaboratively within fast-paced-interdisciplinary research teams.
• Capacity to manage multiple projects simultaneously with scientific rigor and adaptability.
• Excellent written and verbal communication skills, with the ability to present complex scientific concepts effectively.

Preferred Qualifications:

• Prior experience in drug discovery is preferred but not required.
• Experience leveraging human data sources, such as genetic and multi-omics to support discovery and development activities is a plus.
• Experience with neurovascular diseases is a plus.

Adhere to safe work practices and procedures such as aseptic gowning

Relocation support may be available
Work Location Assignment:On Premise

#LI-PFE

The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

COMPANY OVERVIEW

At Pfizer, our purpose is to deliver breakthroughs that transform patients’ lives. Central to this mission is our Research and Development organization, which is dedicated to translating advanced science and innovative technologies into impactful therapies and vaccines. In this role, you will be at the forefront of this effort, helping ensure that daily activities align with Pfizer’s unwavering commitment to quality. Your work will accelerate the delivery of best-in-class medicines to patients globally and support Pfizer’s commitment to making a meaningful difference in healthcare.

ROLE SUMMARY

As a member of the Cardiovascular Discovery Biology team, the Senior Scientist will play a pivotal role in the drug discovery process, from ideation and hypothesis generation to the identification and validation of therapeutic targets and disease-relevant biomarkers.

This individual will contribute to experimental strategy and execution while working closely with scientists across disciplines. Expertise in atherosclerosis biology is essential, and familiarity with different aspects of cardiovascular disease is highly desirable. Daily interactions will take place within a dynamic and supportive environment of innovative scientists. Success in this role requires strong self-motivation, excellent communication and interpersonal skills, and the ability to influence and collaborate effectively in a team setting.

ROLE RESPONSIBILITIES

• Apply scientific expertise and creative thinking to develop strategies for identifying and validating therapeutic targets aligned with IMRU priorities.

• Apply state-of-the-art cellular, molecular, and animal model techniques to investigate mechanisms of atherosclerotic plaque progression, including data analysis and interpretation.

• Stay current with cutting-edge developments in preclinical and translational science and integrate relevant advances into portfolio programs.

• Build and maintain collaborations with academic partners and internal Pfizer scientists.

• Communicate research findings through peer‑reviewed publications, scientific presentations, and internal leadership briefings.

• Uphold the highest standards of scientific integrity, quality, and compliance with regulatory and ethical guidelines.

• Support the development of junior scientists through mentorship and collaborative engagement.

QUALIFICATIONS

Basic Qualifications:

• Ph.D. in Molecular Biology, Biotechnology, Cardiovascular Biology, or related fields.

• A minimum of 1–2 years of postdoctoral or relevant industry experience in drug discovery or translational research.

• Demonstrated expertise in cardiovascular or atherosclerosis disease biology.

• Proficiency in vitro and in vivo cardiovascular-atherosclerotic systems, including foam-cell and vascular-cell assays, molecular biology, high-content imaging, ex vivo approaches, and rodent models of atherosclerosis.

• Strong analytical and problem‑solving capabilities, supported by a track record of impactful scientific contributions.

• Proven ability to work independently and collaboratively within fast-paced-interdisciplinary research teams.

• Capacity to manage multiple projects simultaneously with scientific rigor and adaptability.

• Excellent written and verbal communication skills, with the ability to present complex scientific concepts effectively.

Preferred Qualifications:

• Prior experience in drug discovery is preferred but not required.

• Experience leveraging human data sources, such as genetic and multi-omics to support discovery and development activities is a plus.

• Experience with neurovascular diseases is a plus.

Adhere to safe work practices and procedures such as aseptic gowning

Relocation support may be available
Work Location Assignment:On Premise

#LI-PFE

The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [e-mail]. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Research and Development