Senior Scientific Manager - TS Complex in Vitro Systems

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 121,000 - 225,000; Full time

Benefits offered by this job

Discretionary annual bonus

Job summary

Genentech, a member of the Roche group, is seeking a Sr. Scientific Manager to drive the adoption of blood-brain barrier NAMs across our portfolio. You will align model development across teams, represent Genentech in external consortia, and lead internal data generation to enable molecule progression.

Candidates should hold a Ph.D. in biology or related field, with 1–3+ years in biotechnology or pharma, and hands‑on experience with complex in vitro BBB models (organoids, MPS).

Qualifications

• PhD in biology or related field required or equivalent experience.
• 1–3+ years in biotech/pharma with complex in‑vitro systems.
• Experience developing, qualifying, and applying in‑vitro BBB models (organoids, MPS).

Responsibilities

• Drive BBB model strategy and align BBB strategy across teams.
• Coordinate scientific sharing across REDs and external partners.
• Manage experimental design and data generation for collaborations.
• Train end‑users across internal functions and support model troubleshooting.

Skills

Project management

BBB biology

In vitro modeling

Cross-functional collaboration

Education

PhD in Biology or related field

Tools

BBB models

Organoids

MPS

Job description

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 45 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The Sr. Scientific Manager will help drive and execute our strategy for the adoption and use of blood‑brian‑barrier (BBB) models across the company and development portfolio. In particular, they will be responsible for aligning our model development and validation efforts across the REDs, representing Genentech in external consortia developing blood‑brain‑barrier modeling technologies, and driving internal adoption of blood‑brain barrier modeling technologies in our pharma pipeline. In addition, this position will also be responsible for a portion of routine data generation, including generating data to support project teams, training scientists on usage of in vitro BBB models, and maintaining general laboratory upkeep tasks. Due to combined needs across strategic management, stakeholder organization, and in‑laboratory skills, this position requires a candidate with strong organizational, multi‑tasking, and communication skills, and must feel comfortable in a fast‑paced and diverse research environment.

The Opportunity: As an integral member of our dynamic team, you will: Drive momentum in New Approach Methodologies (NAMs), and collaborate internally across research and development functions to drive adoption of BBB NAMs in our portfolio projects. Join a team of leading scientists driving momentum in New Approach Methodologies (NAMs), and collaborate internally across research and development functions to drive adoption of BBB NAMs in our portfolio projects. Gain exposure to internal molecule development teams and participate by generating data to contribute to molecule progression. Develop external presence and influence by representing Genentech in relevant external consortia on NAM technologies and help guide their activities to represent our interests in BBB and beyond.

Key Responsibilities in Role

• Project management, Strategic Planning and Execution Contribute to and refine our organ area strategy for BBB models, and be responsible for communications and activity updates to project teams, development functions, and leadership teams.
• Play a key role in aligning overall BBB strategy across Roche and Genentech by coordinating scientific sharing across the REDs.
• Track and drive progression of adopting these models across functions.
• Facilitate partnerships with external collaborators, including academic institutions, consortiums, and CROs to drive NAM science that enables adoption..
• Manage external collaborations in the BBB organ area with the above groups, which are a key component of our overall BBB technology strategy.
• Be responsible for both experimental and logistical requirements for these collaborations, e.g. experimental design, compound requests & shipment, etc.
• Act as a central source of knowledge for BBB models used at Genentech, and perform experiments requiring usage of these models to support cross‑functional needs, primarily active research & development requests.
• Perform training of end‑users across internal functions, and provide experimental and scientific support as necessary to aid in model troubleshooting, data interpretation, and development of new assays or models as necessary.
• Participate in maintenance of routine laboratory upkeep tasks, such as stocking, coordinating equipment maintenance, cleanouts, etc.

Who You Are

• Ph.D. in biology, bioengineering, biomedical engineering, pharmacology, or a related field with significant experience in in‑vitro systems; exceptional candidates with equivalent experience will be considered.
• 1-3+ years of experience in pharmaceutical, biotechnology, or research organizations, with a focus on complex in‑vitro systems.
• Proven experience in developing, qualifying, and applying complex in‑vitro BBB models in the form of organoids, MPS, or related platforms in a drug discovery or translational research setting.
• Prior experience in a project management or strategy‑focused role is highly desirable, with demonstrated success in cross‑functional collaboration.

Key Skills and Competencies

• Project management expertise and impeccable organizational skills, with a demonstrated ability to manage multiple priorities effectively.
• Scientific experience and background in blood‑brain barrier biology or neurobiology and in‑vitro modeling.
• Strong understanding of the biological underpinnings and applications of complex in‑vitro systems in drug development.
• Team‑oriented mindset, with a focus on fostering innovation, collaboration, and driving to impact.

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $121,100.00- $224,900 Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life‑threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.