(Senior) Research Scientist, Biology

OnKure Therapeutics; Boulder (CO); On-site; USD 110,000 - 140,000; Full time

Benefits offered by this job

Stock options

Performance-based bonus opportunities

401(k) plan with company match

Insurance coverage (health, dental, &

Paid time off

Job summary

OnKure Therapeutics in Boulder, CO, is seeking a Research Scientist/Senior Research Scientist to advance cell biology and assay programs supporting discovery. You will design, execute, and interpret in vitro studies in-house and with CROs, delivering robust data to inform go/no-go decisions.

We value strong scientific rigor, expertise in cell-based and biochemical assays, and the ability to lead projects with cross-functional teams.

Qualifications

• Ph.D. in Biology, Cell Biology, Molecular Biology, Pharmacology, or related discipline, or an M.S. with 3–5 years' experience.
• Strong data analysis skills and ability to interpret complex datasets.
• Experience supporting preclinical drug development programs or small molecule discovery preferred.

Responsibilities

• Design, execute, and analyze key in vitro assays and in-house experiments
• Follow best practices for assay development and validation, data integrity, and documentation
• Maintain laboratory compliance with internal SOPs and safety regulations
• Develop, optimize, and troubleshoot cell-based, biochemical, and/or biophysical assays to support target validation, mechanism-of-action studies, and lead optimization
• Generate robust, reproducible data packages to inform go/no-go decisions
• Interpret complex biological datasets and present findings clearly to cross-functional teams
• Contribute to experimental strategy and scientific direction within project teams
• Manage timelines, budget, and deliverables for external studies
• Review, analyze, and interpret raw data, ensure scientific rigor, and provide feedback to CRO teams
• Partner with chemistry, pharmacology, translational, clinical, and project management teams to integrate biological insights into broader development strategies
• Contribute to IND-enabling studies and regulatory documentation as needed

Skills

Cell-based assay development

Biological characterization

Data analysis

Independent work

Team collaboration

Education

Ph.D. in Biology or related field

M.S. with 3-5 years industry experience

Tools

Prism

Excel

Job description

OnKure is looking for a Research Scientist/Senior Research Scientist to contribute to and advance cell biology and biological assay programs supporting our discovery pipeline. This individual will develop, execute, and interpret in vitro studies conducted both in-house and through external Contract Research Organizations (CROs).

With strong scientific rigor and expertise in cellular, biochemical, and/or biophysical assay development, the successful candidate delivers high-quality, decision-enabling data.

Job Responsibilities

In-House Lab Contributions:

• Design, execute, and analyze key in vitro assays and in-house experiments
• Follow best practices for assay development and validation, data integrity, and documentation
• Maintain laboratory compliance with internal SOPs and safety regulations

Scientific Leadership

• Develop, optimize, and troubleshoot cell-based, biochemical, and/or biophysical assays to support target validation, mechanism-of-action studies, and lead optimization
• Generate robust, reproducible data packages to inform go/no-go decisions
• Interpret complex biological datasets and present findings clearly to cross-functional teams
• Contribute to experimental strategy and scientific direction within project teams

CRO And External Collaboration Management

• Manage timelines, budget, and deliverables for external studies
• Review, analyze, and interpret raw data, ensure scientific rigor, and provide feedback to CRO teams
• Contribute to experimental design decisions
• Maintain strong, proactive communication to ensure alignment and quality

Cross-Functional Collaboration

• Partner with chemistry, pharmacology, translational, clinical, and project management teams to integrate biological insights into broader development strategies
• Contribute to IND-enabling studies and regulatory documentation as needed
• Support external presentations, publications, and investor materials as appropriate

Preferred Experience And Qualifications

• Research Scientist: Ph.D. in Biology, Cell Biology, Molecular Biology, Pharmacology, or related discipline or equivalent experience (or M.S. plus 3-5 years’ experience)
• Senior Research Scientist: Ph.D. in Biology, Cell Biology, Molecular Biology, Pharmacology, or related discipline with 3+ years of relevant industry experience (or M.S. with 8+ years)
• Expertise in cell-based assay development and biological characterization
• Strong data analysis skills (e.g., Prism, Excel, and statistical interpretation)
• Proven ability to work independently while contributing to team-based science
• Small molecule drug discovery experience preferred
• Experience supporting preclinical drug development programs preferred

About OnKure

We are a clinical-stage biopharmaceutical company focused on discovering and developing precision medicines that target biologically validated drivers of diseases underserved by available therapies. Using a structure- and computational chemistry-driven drug design platform, we are committed to improving clinical outcomes for patients by building a robust pipeline of small-molecule drugs designed to selectively target specific mutations thought to be key drivers of cancer and vascular anomalies.

To attract the very best talent, OnKure offers a generous compensation and benefits package that includes competitive pay, performance-based bonus opportunities, stock options, insurance coverage (health, dental, life, and disability) for full-time employees, self-managed paid time off, and a 401(k) plan with company match.

Candidates who live in or are willing to relocate to the Boulder, CO area are preferred.

The annual compensation range for this role, based on experience, is $110,000-$140,000. Job level and compensation are dependent on relevant education and experience.

OnKure is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, protected veteran status, disability, or any other protected factors.