Senior Research Associate II, Medicinal Chemistry

BioSpace; South San Francisco (CA); On-site; USD 120,000 - 147,000; Full time

Benefits offered by this job

Medical, dental, and vision insurance

Equity incentive plan

401(k) with employer match

Generous PTO policy

Job summary

A biopharmaceutical company in South San Francisco seeks a Senior Research Associate II in Medicinal Chemistry. The role involves applying expertise in organic chemistry to synthesize and characterize novel molecules. Ideal candidates have a B.S./M.S. in Chemistry and at least 4 years of relevant experience. Responsibilities include executing syntheses, proposing new compounds, and collaborating with multidisciplinary teams. The expected salary ranges from $120,000 to $147,000 annually, plus performance bonuses.

Qualifications

• At least 4 years of relevant experience in synthetic organic or medicinal chemistry.
• Experience in organic synthesis and analytical techniques.

Responsibilities

• Execute multistep syntheses of complex small molecules.
• Propose new compounds for synthesis based on SAR.
• Collaborate with scientists to develop and optimize molecules.

Skills

Organic synthesis

Chromatographic purification

Compound characterization using NMR

Attention to detail

Strong communication skills

Education

B.S./M.S. in Chemistry

Tools

NMR

LCMS

HPLC

Job description

Senior Research Associate II, Medicinal Chemistry

Apply for the Senior Research Associate II, Medicinal Chemistry role at BioSpace.

The Position

Join our innovative drug discovery team as a Senior Research Associate II. In this role, you’ll apply your expertise in organic and medicinal chemistry to synthesize, purify, and characterize novel molecules that could lead to breakthrough therapies. You’ll work hands‑on with cutting‑edge techniques and collaborate across functions to advance our research programs.

Impact You’ll Have

• Execute multistep syntheses of complex small molecules and characterize intermediates and final products.
• Propose new compounds for synthesis based on SAR and synthetic knowledge.
• Summarize and interpret results and present findings in research meetings.
• Learn new laboratory techniques, troubleshoot experiments, and ensure high-quality execution.
• Utilize scientific literature and databases (e.g., SciFinder) to design efficient synthetic routes.
• Collaborate with scientists across functions to develop and optimize newly generated molecules.

What We’re Looking For

• B.S./M.S. in Chemistry with at least 4 years of relevant experience in synthetic organic or medicinal chemistry.
• Demonstrated experience in organic synthesis, chromatographic purification, and compound characterization using modern analytical techniques (NMR, LCMS, HPLC, etc.).
• Strong organizational skills and attention to detail.
• A proactive, solution‑oriented approach and commitment to collaboration.
• Ability to learn and adapt in a fast‑paced environment.
• Excellent verbal and written communication skills.

About Maze Therapeutics

Maze Therapeutics is a clinical‑stage biopharmaceutical company harnessing the power of human genetics to develop novel, small‑molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine‑based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

• Further Together – Our path is paved with challenges, but with resilience and a team‑first mentality, we’ll achieve our mission.
• Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
• Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $120,000 – $147,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position‑based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job‑related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

Seniority Level

Mid‑Senior level

Employment Type

Full‑time

Job Function

Research, Analyst, and Information Technology

Industries

Internet News