Senior Research Associate, High-Throughput RNA Production

Sail Biomedicines; Cambridge (MA); On-site; USD 75,000 - 95,000; Full time

Job summary

Sail Biomedicines is seeking a Senior Research Associate for high-throughput RNA production in Cambridge, MA. The role involves end-to-end RNA generation from cloning to IVT and purification, under fast-paced conditions that emphasize accuracy and collaboration.

You will manage plasmid constructs, coordinate with external vendors, and maintain thorough records while contributing to team discussions and process improvements.

Qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences.
• Ability to manage multiple tasks at once efficiently.
• Strong collaborative spirit and communication skills.
• Excellent record keeping.

Responsibilities

• Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT).
• Determine circularization efficiency and impurity levels by running analytic assays.
• Coordinate DNA synthesis and scale-up orders with external vendors.
• Manage raw material and RNA inventories.
• Collaborate with automation engineer to improve process workflow.
• Maintain detailed documentation in electronic lab notebooks.
• Present findings clearly to platform teams and contribute to scientific discussions and decision-making.

Skills

Multi-tasking

Collaboration

Record keeping

Education

B.S. in Life Sciences, Chemistry, Engineering, or related field

M.S. in Life Sciences

Tools

HPLC

Automated liquid handling (Hamilton)

Benchling

Excel

File/Inventory management

Job description

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ oreRNA), and an industry-leading platform of programmable nanoparticles,utilizingnatural components, to unlock comprehensive programming of medicines for the first time. Byleveragingcutting-edgeeRNAand nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques toidentifyand design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

The Senior Research Associate, high-throughput (HTP) RNA production, serves an important role in generating RNAs to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role will carry out end-to-end process of high-throughput RNA production, from template plasmid cloning to RNA generation and clean up. The successful candidate is organized, attentive to details, a fast learner with a strong sense of responsibility who takes pride in his/her work. The team looks forward to helping you stride in this exciting and fast-paced environment to make a real-world impact on patients’ lives.

Responsibilities

• Perform high-throughput cloning of plasmid constructs and RNA generation through in vitro transcription (IVT)
• Determine circularization efficiency and impurity levels by running analytic assays
• Coordinate DNA synthesis and scale-up orders with external vendors
• Manage raw material and RNA inventories
• Collaborate with automation engineer to improve process workflow
• Maintain detailed documentation in electronic lab notebooks
• Present findings clearly to platform teams and contribute to scientific discussions and decision-making

Qualifications

• B.S. in Life Sciences, Chemistry, Engineering, or a related field with 2+ years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
• Ability to manage multiple tasks at once efficiently
• Strong collaborative spirit and communication skills
• Excellent record keeping

Preferred Qualifications

• Experience in molecular biology including cloning, RNA production and purification
• Familiarity with high-performance liquid chromatography (HPLC) or other column-based purification/analytic methods
• Experience with automated liquid handling systems (e.g., Hamilton) and high-throughput laboratory workflows
• Experience using data analysis and information management tools, such as Excel, Graphic Prism, SnapGene, Benchling
• Experience in inventory management

Salary Range:

$75,000 - $95,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.