Senior Research Associate

Freenome; United States; On-site; USD 98,000 - 126,000; Full time

Benefits offered by this job

Equity

Cash bonuses

Medical benefits

Job summary

Freenome is seeking a Senior Research Associate to advance genomic assay technologies within the Genomic Early Development team. The role collaborates with Scientists, Automation Engineers, and Computational Biologists to create automated workflows, improving throughput in a regulated lab setting at our Brisbane, CA headquarters.

You will design experiments, optimize NGS-based methods, and ensure quality by complying with cGLP/cGDP while coordinating with QA, Manufacturing, and Regulatory to

Qualifications

• Bachelor’s degree with 4+ years life sciences experience or Master’s in related field.
• Hands-on NGS assay development experience.
• Experience with molecular biology workflows and sample prep.
• Ability to design, plan, and execute experiments with data review.
• Strong attention to detail and troubleshooting skills.
• Clear communication and collaboration skills.
• Willingness to learn and adapt to changing priorities.

Responsibilities

• Develop and optimize NGS workflows including DNA/RNA extraction, library prep, target capture, and sequencing.
• Operate and maintain NGS instruments.
• Test new reagents and develop QC methods.
• Troubleshoot issues and improve analytical workflows.
• Collaborate to transfer assays from Research to Development.
• Transfer QC methods and manufacturing processes to Operations.
• Record results in electronic lab notebooks and author study protocols.
• Apply cGLP and cGDP practices.

Skills

Molecular biology

NGS assay development

Experimental design

Data interpretation

Pipetting accuracy

Documentation

Team collaboration

Process improvement

Flexible learner

Education

Bachelor's degree in molecular biology/biochemistry

Master's degree in molecular biology

Tools

Automated liquid handlers

PCR instruments

Sequencers

Job description

About this opportunity:

At Freenome, we are seeking a Senior Research Associate to help grow the Freenome Genomic Early Development team. As a Senior Research Associate, you will participate in the development of genomic assay technologies and contribute to Freenome’s multiomic product portfolio aimed at early cancer detection. You will work closely with Scientists, Automation Engineers, and Computational Biologists to develop, optimize, and characterize efficient automated workflows to improve experimental and clinical throughput in a regulated high throughput environment. You will also work with Operations, Quality, and Regulatory to transfer complex methodologies, processes, and assays to Operations to ensure the highest quality data is produced by our clinical lab. You are passionate about contributing to developing life-saving diagnostics through early cancer detection, and you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.

The role reports to the Senior Manager of Genomic Early Development team. This role will be an Onsite role based in our Brisbane, California headquarters.

What you’ll do:

• Apply hands‑on knowledge of molecular biology, nucleic‑acid biochemistry and next generation sequencing to develop and optimize NGS based methods and processes following principles of Design Controls for IVD development.
• Design and perform experiments to develop, optimize, and characterize NGS workflow including DNA/RNA extraction, library preparation, target capture, and sequencing.
• Operate and maintain NGS related instruments such as automated liquid handlers, PCR instruments, and sequencers.
• Conduct new reagents testing and develop reagent quality control methods.
• Participate in troubleshooting issues, identify and implement process improvement for the entire analytical workflow.
• Collaborate with research, computational scientists, and automation engineers to transfer research prototype assays from Research to Development.
• Collaborate with Quality Control Lab, Manufacturing lab, Quality, and Regulatory to transfer reagent quality control methods and manufacturing processes from Development to Operations and support the implementation of the methods and processes in Operations.
• Accurately record results in electronic lab notebooks, author work instructions and record forms, contribute to writing study protocols and reports. Diligently apply current Good Laboratory and Documentation Practices (cGLP, cGDP).

Must haves:

• Bachelor’s in molecular biology, biochemistry, or a related field with at least 4 years of experience in the life sciences or Master’s in molecular biology or a related field.
• Hands‑on experience in Next‑gen sequencing (NGS) based assay development including extraction, library preparation, target capture, and sequencing.
• Familiarity with molecular biology, genomics, NGS, assay development, sample preparation, reagent handling, or related laboratory workflows (e.g. plasma separation processes, DNA/RNA extraction, purification, and quantification, NGS library preparation).
• Experience designing, planning, and executing successful experiments, interpreting results, preparing data for review, and giving effective scientific presentations.
• High attention to detail and ability to record accurate and detailed observations, assess impact, and perform troubleshooting as required.
• Ability to manually pipette with high confidence, accuracy, and precision.
• Clear and proactive communication skills and ability to collaborate effectively with team members in the same and adjacent disciplines.
• Strong organizational skills and the ability to contribute the design and implementation of new processes.
• Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities.

Nice to haves:

• Experience in working with with methylated ctDNA/cfDNA as an analyte in liquid biopsy workflows.
• Experience with automated liquid handlers, laboratory information systems, sample tracking systems, and equipment scheduling/status tools.
• Familiarity with programing in a scientific programming language (e.g., Python or R).

Benefits and additional information:

The US target range of our base salary rate for new hires is $97,850 - $126,000. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.

Freenome is proud to be an equal‑opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Applicants have rights under Federal Employment Laws.

• Family & Medical Leave Act (FMLA)
• Equal Employment Opportunity (EEO)
• Employee Polygraph Protection Act (EPPA)

California applicants please review the CCPA Notice at Collection here:

• California Consumer Privacy Act (CCPA)

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