Senior Research Assistant & Lab Manager – AML

Cincinnati Children's; Cincinnati (OH); On-site; USD 53,000 - 72,000; Full time

Job summary

Cincinnati Children’s seeks an experienced Research Assistant who will serve as a senior research professional and laboratory manager in a translational leukemia research laboratory focused on understanding and overcoming mechanisms of targeted therapy resistance in acute myeloid leukemia (AML).

This position will support both scientific and operational aspects of the laboratory, including experimental execution, laboratory organization, regulatory compliance, trainee support, and inventory

Qualifications

• Bachelor's degree in a related field AND 1 year of directly related experience OR Master's degree in a related field
• Bachelor's degree in a related field; 3 years of experience in related job discipline OR Master's degree and 2 years experience

Responsibilities

• Perform and troubleshoot molecular and cellular biology experiments with minimal supervision.
• Maintain and characterize leukemia cell lines and primary patient samples.
• Conduct tissue culture studies, in vitro drug treatment experiments, and mechanistic studies of therapeutic response and resistance.
• Perform protein-based analyses, including immunoblotting, immunoprecipitation (IP), coimmunoprecipitation (co-IP).
• Isolate DNA and RNA from cells, tissues, and animal samples.
• Prepare samples for next-generation sequencing and assist with sequencing-based studies.
• Support in vivo studies, including planning, coordination, sample collection, and analysis of mouse experiments.
• Maintain accurate, detailed, and well-organized experimental records and laboratory notebooks.
• Analyze, summarize, and present experimental findings at laboratory meetings.
• Oversee day-to-day laboratory operations and ensure efficient workflow.
• Manage laboratory inventory, purchasing, equipment maintenance, and vendor interactions.
• Develop and maintain laboratory SOPs and organizational systems.
• Coordinate laboratory onboarding and training of students, staff, and trainees.
• Monitor compliance with institutional safety, biosafety, animal use, and regulatory requirements.
• Assist with laboratory resource allocation.
• Foster a collaborative and productive laboratory environment.

Skills

Mammalian tissue culture

DNA & RNA isolation

Protein biochemistry

Molecular biology techniques

In vitro drug treatment studies

Mouse research

Leukemia/cancer biology

Primary patient samples

Education

Bachelor's degree in related field

Master's degree in related field

Job description

Cincinnati Children’s seeks an experienced Research Assistant who will serve as a senior research professional and laboratory manager in a translational leukemia research laboratory focused on understanding and overcoming mechanisms of targeted therapy resistance in acute myeloid leukemia (AML).

This position will support both scientific and operational aspects of the laboratory, including experimental execution, laboratory organization, regulatory compliance, trainee support, and inventory