Senior/Principal Scientist, Protein Engineering

Dovetail Therapeutics; Seattle (WA); On-site; USD 100,000 - 140,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Paid parking or transit

401(k) plan

Paid time off

Job summary

A biotechnology company in Seattle is seeking a passionate Senior/Principal Scientist to lead antibody discovery and optimization efforts. The ideal candidate holds a Ph.D. and has over 5 years of experience in protein engineering, particularly in an industry setting. This full-time position offers a collaborative environment, competitive compensation, and a comprehensive benefits package.

Qualifications

• 5+ years of experience in antibody discovery and protein engineering.
• 2+ years of industry experience strongly preferred.
• Excellent organizational and communication skills.

Responsibilities

• Lead and contribute to discovery efforts for antibody candidates.
• Work with teams to design and advance biotherapeutics.
• Develop strategies and methodologies to accelerate antibody discovery.

Skills

Expertise in antibody and protein science

Hands-on experience in therapeutic protein engineering

Proven ability in antibody engineering approaches

Skilled in sequence analysis and structural modeling

Ability to synthesize functional data

Current on emerging trends in protein design

Education

Ph.D. in structural biology, molecular biology, biochemistry

Job description

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Dovetail Therapeutics is seeking a talented and motivated Senior/Principal Scientist to join our growing and dynamic team. If you are passionate about developing new technologies and contributing to the next generation of biotherapeutics in a collaborative and fast-paced environment where your contributions will make a real difference, this role is for you.

Key Duties and Responsibilities

• Lead and contribute to discovery and optimization efforts for antibody candidates
• Work with internal cross-functional teams and CROs to design and advance novel biotherapeutics
• Develop and implement innovative strategies and methodologies to accelerate antibody discovery and engineering workflows
• Analyze and effectively communicate ideas and findings to internal stakeholders

Knowledge and Skills

• Expertise in antibody and protein science, molecular biology, and biotherapeutic discovery
• Hands‑on experience in therapeutic protein and antibody engineering, particularly with optimization of molecular properties, affinity maturation, and/or antibody humanization
• Proven ability in applying state‑of‑the‑art antibody engineering approaches and computational tools to shape design strategy and optimize workflows
• Skilled in sequence analysis and structural modeling for protein design
• Ability to synthesize functional and biophysical data and integrate high‑throughput datasets to guide selection and engineering strategies
• Stay current on emerging trends in protein design and introduce innovative techniques to expand team capabilities

Qualifications

• Ph.D. degree in structural biology, molecular biology, biochemistry or a related field
• 5+ years of experience in antibody discovery and protein engineering in an academic or industry setting; 2+ years of industry experience strongly preferred
• Excellent organizational and communication skills with attention to detail
• Ability to work in a fast‑paced, interdisciplinary environment

About Dovetail Therapeutics

Dovetail Therapeutics is bringing life‑changing therapies to patients through its novel, next‑generation technologies. We are located at 1616 Eastlake Ave East in the vibrant South Lake Union area of Seattle. We foster a culture of collaboration and innovation in which every employee plays a critical role in shaping our success. Dovetail offers a competitive total compensation and benefits package. Benefits include medical, dental and vision coverage, paid parking or transit, a 401(k) plan, and paid time off, among other components.

Seniority level

Mid‑Senior level

Employment type

Full‑time

Job function

Research, Analyst, and Information Technology