Senior Principal Scientist Oligonucleotides

BioSpace; Cambridge (MA); On-site; USD 180,000 - 250,000; Full time

Job summary

Amgen in Cambridge, MA seeks a Senior Principal Scientist to lead oligonucleotide process development and manufacturing technology transfers. You will manage a multidisciplinary chemist/engineer team, drive process improvements, ensure GMP compliance, and support regulatory filings.

The role focuses on scalable manufacturing processes, cross-functional collaboration, and cutting-edge bioconjugate technology development within a global biotech leader.

Qualifications

• PhD/MD/PharmD required with relevant post-doc experience.
• Experience leading oligonucleotide process development and tech transfer.
• Strong GMP/CMC regulatory experience and cross-functional leadership.

Responsibilities

• Lead a multidisciplinary team to develop cost-effective oligonucleotide manufacturing processes.
• Collaborate with cross-functional teams to expand capacity and improve yield.
• Drive technology innovation and oversee regulatory documentation.
• Support cGMP manufacturing and tech transfer to GMP facilities.
• Mentor staff and ensure project deliverables meet timelines.

Skills

Scientific leadership

Oligonucleotide process development

GMP manufacturing

Technology transfer

Cross-functional leadership

Education

PhD/MD/PharmD

Master's degree

Bachelor's degree

Tools

CMC knowledge

CMC documentation

Job description

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Process Development Senior Principal Scientist Bioconjugates

What you will do

Lets do this. Lets change the world. In this vital role you will Amgens DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets. Process chemists within our team to apply their training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

Amgen is currently seeking a talented Senior Principal Scientist who will lead a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes, drive capacity expansion projects,and lead technology transfers for oligonucleotides. The candidate will drive technology innovation, provide technical expertise, and develop and mentor staff within the organization. The successful candidate for this role will be a people-centered leader with deep expertise in oligonucleotide process development and industrialization with a proven track record of scientific innovation and leadership within the pharmaceutical industry. The role will be located at either our Thousand Oaks, California or Cambridge, Massachusetts campus.

• Lead a multidisciplinary project team in the development of sustainable and cost-effective processes for oligonucleotide manufacturing.
• Work with cross-functional teams to develop strategies and implementation plans to expand production capacity and improve yield.
• Drive oligonucleotide technology innovation
• Support cGMP manufacturing and technology transfer to GMP production facilities
• Develop strategies to ensure process performance through process understanding, modeling and characterization
• Guide successful completion of project deliverables and ensure timelines are met
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugate manufacturing
• Coach and provide career and scientific / technical advice to colleagues within the organization

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of Scientific experience OR
• Masters degree and 6 years of Scientific experience OR
• Bachelors degree and 8 years of Scientific experience

Preferred Qualifications

• Doctoral degree and 6+ years in the pharmaceutical industry with expertise in oligonucleotide process development
• GMP manufacturing and technology transfer to CMOs
• Demonstrated functional representation on a CMC or PDT team
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
• Proven track record of publications, patents and presentations

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.