Senior Principal Scientist, Bioanalysis

Scorpion Therapeutics; Spring House (PA); On-site; USD 180,000 - 240,000; Full time

Job summary

Johnson & Johnson Innovative Medicine in Spring House, PA, seeks a Senior Principal Scientist, Bioanalysis, to lead bioanalytical assay development and validation, focusing on large‑molecule immunoassays and multiplex workflows.

You will design and oversee assay lifecycles, ensure GLP/GCLP compliance, support regulatory filings, transfer to CROs, and mentor a skilled team while evaluating new technologies.

Qualifications

• PhD in Biology, Immunology, Biochemistry or Analytical Chemistry with 8+ years in regulated bioanalysis.
• Hands-on expertise in immunoassays for large molecules (MSD, Gyrolab, ELISA).
• Familiarity with automation, GLP/GCLP and regulatory guidelines (ICH M10).

Responsibilities

• Develop and validate bioanalytical assays, including LBA and LC-MS.
• Oversee assay lifecycle, reagent management, and stability programs.
• Prepare scientific and regulatory documentation for submissions.
• Mentor staff and evaluate emerging technologies.

Skills

Immunoassays

GLP/GCLP compliance

Leadership

Communication

Regulatory knowledge

Education

PhD in Biology/Immunology/Biochemistry/Analytical Chemistry

Job description

Role

Senior Principal Scientist, Bioanalysis, leading bioanalytical assay development and validation within Johnson & Johnson's Innovative Medicine division.

Responsibilities

serve as development PK representative, design and troubleshoot immunoassays (LBA and LC-MS), oversee assay lifecycle including validation, reagent management, and stability programs; prepare scientific and regulatory documentation; ensure compliance with GLP/GCLP standards; support regulatory submissions and assay transfer to CROs; mentor staff; evaluate emerging technologies; communicate findings internally and externally.

Requirements

Ph.D. in Biology, Immunology, Biochemistry, or Analytical Chemistry with 8+ years (or MS with 10+ years) in regulated bioanalysis; deep hands-on expertise in immunoassays for large molecules (MSD, Gyrolab, ELISA); proven experience with complex modalities (oligonucleotides, ADCs); familiarity with automation, GLP/GCLP, and regulatory guidelines (ICH M10); strong communication and matrix leadership skills.

Preferred

experience in hybrid LBA-LC-MS, immunogenicity assays, regulatory filings, and staff training; knowledge of orthogonal bioanalytical methods.

High Value

biologics, complex modalities, regulated bioanalysis, GLP/GCLP, assay validation, assay transfer, regulatory support.

Location

Spring House, PA.