Senior / Principal Scientist, AOC Process Development (Bioconjugation & Scale-Up)

Myoventive, Inc.; South San Francisco (CA); On-site; USD 160,000 - 230,000; Full time

Job summary

Myoventive, Inc. is seeking a highly skilled Senior to Principal Scientist to join the Protein Science team.

The role focuses on antibody-oligonucleotide conjugate (AOC) production at in vivo-enabling scale, optimizing conjugation and purification workflows, and delivering dosing-ready material for pharmacology and PK/PD studies. The candidate will drive process development, characterization, and cross-functional collaboration in a fast-moving biotech environment, with emphasis on robust,

Qualifications

• Ph.D. required in a related field with 5+ years for Senior Scientist or 8+ years for Principal Scientist.
• Hands-on bioconjugation chemistry and development/optimization of conjugation and purification workflows.
• Experience producing/purifying bioconjugates at 100 mg to gram scale for in vivo studies.
• Knowledge of analytical methods for protein conjugates (SEC, IEX/HIC, LC-MS, CE-SDS) and independent experimental design.

Responsibilities

• Develop and execute protein-oligonucleotide conjugation processes at in vivo-enabling scale.
• Optimize conjugation conditions for yield, quality, and reproducibility.
• Plan and execute AOC production with purification and buffer exchange workflows.
• Collaborate across teams on design, analytics, and study timelines.

Skills

Bioconjugation

Process development

Purification workflows

Analytical methods

Experiment design

Education

Ph.D. in Chemistry/Biochemistry/Chemical Engineering/Chemical Biology

Tools

SEC

IEX/HIC

LC-MS

CE-SDS

Job description

Myoventive is a precision-cardiology therapeutics company developing next-generation oligonucleotide-based medicines to transform the treatment of genetic heart disease. We are seeking a highly skilled and hands-on Senior to Principal Scientist to join our Protein Science team.

This role will focus on developing and executing antibody-oligonucleotide conjugate (AOC) production processes at in vivo-enabling scale. The successful candidate will optimize conjugation and purification workflows and deliver reproducible, high-quality AOC material for pharmacology and PK/PD studies.

This position is ideal for a scientist who thrives at the bench, enjoys solving conjugation, purification, and scale-up challenges, and wants to apply deep bioconjugation and process development expertise to a novel therapeutic modality in a fast-moving biotech environment. The role is expected to deliver dosing-ready AOC material on study timelines while establishing robust and repeatable production workflows.

Key Responsibilities

• Develop and execute protein-oligonucleotide conjugation processes at in vivo-enabling scale, including approximately 100 mg batches for preclinical studies, with further scale-up to support planned non-human primate studies.
• Optimize conjugation conditions to improve efficiency, yield, product quality, and batch-to-batch reproducibility.
• Identify and resolve process challenges including aggregation, conjugation efficiency, reagent losses, solubility limitations, and product heterogeneity.
• Optimize reagent utilization and recovery, particularly for supply-limiting oligonucleotide and linker inputs.

Purification & Material Supply

• Develop and execute preparative purification workflows for AOCs using appropriate chromatography and filtration approaches.
• Develop buffer exchange and concentration workflows to support dosing requirements and downstream studies.
• Plan and execute AOC production campaigns against study timelines, coordinating antibody supply and externally sourced oligonucleotide and linker inputs.

Process Characterization & Documentation

• Establish process controls and fit-for-purpose QC criteria to support consistent AOC production.
• Work closely with Protein Analytics to assess identity, purity, aggregation, free oligonucleotide, concentration, and other relevant product attributes.
• Evaluate material stability and handling requirements, including storage, freeze-thaw, shipping, and dosing conditions.
• Develop and document workflows, batch records, and SOPs to support reproducible execution and future external process transfer as needed.

Cross-Functional Collaboration & Platform Development

• Work closely with colleagues to align conjugate design, analytical characterization, material requirements, formulation, and study timelines.
• Communicate clearly and proactively on timelines, technical risks, and material requirements.
• Use process and scale-up learnings to inform molecule design and contribute to advancement of the AOC platform and related intellectual property.

Qualifications

Required:

• Ph.D. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or related field.
• 5+ years of relevant industry experience for Senior Scientist; 8+ years for Principal Scientist.
• Strong hands-on experience with bioconjugation chemistry, including development and optimization of conjugation and purification workflows.
• Demonstrated hands-on experience producing and purifying bioconjugates at approximately 100 mg to gram scale for in vivo studies, including preparative chromatography.
• Working knowledge of analytical methods used to characterize protein conjugates, such as SEC, IEX/HIC, LC-MS, and CE-SDS.
• Experience independently designing experiments and driving technical problems to resolution under study timelines.

Preferred:

• Prior experience with AOCs, ADCs, or related bioconjugate modalities.
• Experience with oligonucleotide payloads (ASO, siRNA, PMO), including handling, purification, and stability considerations.
• Experience with scale-up purification, buffer exchange, and concentration workflows for protein or bioconjugate therapeutics.
• Experience supporting preclinical material production, process transfer, or CMC development.
• Experience working in early-stage or fast-paced biotech environments.
• Strong experimental rigor, process discipline, and problem-solving skills.
• Ability to operate as a senior individual contributor within a multidisciplinary team.
• Ability to manage production activities against study timelines and material requirements.
• Clear communication of complex technical data, risks and mitigations to scientific colleagues.
• Adaptability and enthusiasm for developing new therapeutic modalities.

Myoventive is is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or any other protected status under applicable federal or state law. All employment decisions are based on qualifications, merit, and business needs.