Senior Principal Scientist

Bristol Myers Squibb; Seattle (WA); On-site; USD 175,166 - 183,690; Full time

Benefits offered by this job

Health coverage

Well‑being programs

401(k) plan

Paid time off

Job summary

Bristol Myers Squibb in Seattle, WA seeks a Senior Principal Scientist to advance cellular drug development within the CMC program and drive product release through analytical strategy and cross‑functional collaboration.

The role involves applying CRISPR-Cas9 gene editing, analyzing large clinical datasets, and preparing regulatory submissions (INDs, BLAs) while supporting QC and process characterization.

Qualifications

• Master’s degree or foreign equivalent in Biochemistry, Molecular Biology, or related field.
• Four (4) years of work experience as a Medical Scientist or related occupation.
• Experience developing CMC analytical strategies for cell and gene therapy products and biologics.
• Experience utilizing gene editing technologies such as CRISPR-Cas9 to create engineered T-cells.
• Experience analyzing large datasets for multiple clinical cellular products.
• Experience drafting technical regulatory filings including IND amendments, BLAs, briefing books, and regulatory responses.
• Experience developing and transferring cellular or biologics analytical methods suitable for use in QC or product characterization.

Responsibilities

• Use technical knowledge to support development of cellular drugs in the CMC program.
• Act as a resource for the Cell Therapy Analytical Development department in support of product release, characterization, and in-process testing of cellular drug products.
• Prepare actionable strategies to ensure alignment with business objectives.
• Implement analytical strategy to ensure successful project execution.
• Collaborate with various teams to build cellular process.
• Conduct DP analytical risk identification, assessment, and mitigation.
• Justify drug product specifications for clinical programs.
• Serve as an author for analytical sections of CMC submissions and respond to regulatory questions.
• Telecommuting permitted up to 2 days per week.

Skills

CMC analytics

CRISPR-Cas9

Data analysis

Regulatory filings

Cell therapy analytics

Education

Master’s degree in Biochemistry or Molecular Biology

Job description

Senior Principal Scientist

Job Summary

Senior Principal Scientist at Bristol Myers Squibb in Seattle, WA. Wage range: $175,166 - $183,690.

Responsibilities

• Use technical knowledge to support development of cellular drugs in the Chemical Manufacturing Control (CMC) program.
• Act as a resource for the Cell Therapy Analytical Development department in support of product release, characterization, and in-process testing of cellular drug products.
• Prepare actionable strategies to ensure alignment with business objectives.
• Implement analytical strategy to ensure successful project execution.
• Collaborate with various teams to build cellular process.
• Conduct DP analytical risk identification, assessment, and mitigation.
• Justify drug product specifications for clinical programs.
• Serve as an author for analytical sections of CMC submissions and respond to regulatory questions.
• Telecommuting permitted up to 2 days per week.

Requirements

• Master’s degree or foreign equivalent in Biochemistry, Molecular Biology, or related field.
• Four (4) years of work experience as a Medical Scientist or related occupation.
• Experience developing CMC analytical strategies for cell and gene therapy products and biologics.
• Experience utilizing gene editing technologies such as CRISPR-Cas9 to create engineered T-cells.
• Experience analyzing large datasets for multiple clinical cellular products.
• Experience drafting technical regulatory filings including IND amendments, BLAs, briefing books, and regulatory responses.
• Experience developing and transferring cellular or biologics analytical methods suitable for use in QC or product characterization.

Compensation

Base salary range of $175,166 - $183,690 per year, plus an annual discretionary bonus and various incentive cash and stock opportunities based on eligibility.

Benefits

• Health coverage: medical, pharmacy, dental, and vision care.
• Well‑being support programs and employee assistance programs.
• 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit.
• Paid time off, flexible time off (unlimited PTO for exempt employees), paid vacation, paid sick time, volunteer days, summer hours flexibility, and leaves of absence.

Equal Opportunity Employer

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.