Senior/Principal Scientist

Antharis Therapeutics, Inc.; San Diego (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Antharis Therapeutics, Inc. in San Diego seeks a Senior/Principal Scientist to drive antibody discovery and development programs. You will lead immunotherapy asset development, from target selection to in vivo validation, with hands-on bench work and strategic input.

The role requires a PhD with 5+ years in antibody science, strong data analysis, collaboration with cross-functional teams, and the ability to guide projects to preclinical milestones, while maintaining rigorous scientific standards.

Qualifications

• Ph.D. in Immunology, Biochemistry, or related field with 5+ years post-doc or industry antibody discovery experience.
• Experience leading biologics discovery efforts toward pre-clinical or clinical stages.
• Hands-on antibody discovery using hybridoma and/or B cell technologies.
• Strong communication and collaboration skills, with ability to report to leadership.

Responsibilities

• Lead antibody discovery and development programs from target to asset.
• Design immunogens and immunization strategies; perform screening and validation.
• Oversee in vitro and in vivo tests to assess asset efficacy.
• Manage day-to-day bench operations and project timelines within scope and budget.
• Report progress to CEO/CSO/Board as required.

Skills

Communication skills

Teamwork

Leadership

Hybridoma & B cell cloning

ELISA

Flow cytometry

Cell culture

Immunoassays

Mouse handling

Education

Ph.D. in Immunology, Biochemistry, or related field

Tools

Hybridoma platform

Single B cell platform

Immunogen design

Job description

Careers

Senior/Principal Scientist

We are currently offering a fantastic career opportunity for a highly motivated and experienced antibody discovery/development scientist to join Antharis Therapeutics, a pre-clinical company based in San Diego. The company is committed to the discovery and development of novel immunotherapeutics (monoclonal antibodies and antibody-drug conjugates) for an array of disease states. The approaches for antibody discovery, including hybridoma technology, aim to streamline the development of lead candidates for entering the clinic in an expedited fashion.

The individual selected for this position will be responsible for antibody discovery and development programs. These include intellectual input and decision-making on protein targets to be pursued, development of immunogens and immunization strategies, utilization of hybridoma technology, and antibody validation in vitro and in vivo.

This position requires a strong, highly motivated, and fully independent scientist who will use a hands-on approach on the bench to develop therapeutic antibodies. In alignment with the company’s leadership, this individual will lead the immunotherapeutic product development efforts and, consequently, will have significant intellectual input in the direction of the asset pipeline. A strong work ethic and successful development of lead candidates will provide this individual with a potentially life-transforming professional opportunity.

Essential Job Functions

• Based on unmet medical needs, propose/identify and carry out research on novel targets.
• Custom monoclonal antibody discovery and development of therapeutic candidates.
• Lead the effort of discovering therapeutic antibodies with hybridoma and B cell cloning platforms. More specifically, select and design immunogens during the monoclonal antibody discovery phase, set and implement immunization strategies, and generate, screen, and evaluate hybridomas and B cell candidates.
• Coordinate and carry out in vitro and in vivo tests to probe asset efficacy.
• Ensure rapid and high-quality project advancement.
• Responsible for the leadership over each project and day-to-day bench operations, including target identification and discussions, developing project plans, carrying out experiments from conception to asset development and testing, and controlling project execution to ensure completion of projects to scope, schedule, and budget.
• Responsible for ensuring project risks, both technical and management risks, are identified and appropriately addressed and develop risk mitigation plans.
• Regularly assess and report the status of the projects directly to the CEO, CSO, or, whenever required, to the Board of Directors.
• Drive day-to-day project activity to achieve results, including solving technical and other project challenges, managing resource conflicts, and breaking down barriers to meet product development deadlines and company goals and objectives.
• Establish relationships with core facility operators/managers and collaborators in the area to expand the company’s technical and intellectual capabilities.

Position Requirements

• Ph.D. in Immunology, Biochemistry, or a related field, with 5+ years of post-doc or corporate antibody discovery and development experience.
• Solid knowledge and understanding of the full workflow of therapeutic antibody discovery and development.
• Hands-on experience developing monoclonal antibody therapeutics using hybridoma and/or single B cell platform.
• Track record of leading biologics discovery efforts to advance pre-clinical projects, ideally to the clinical stage.
• Excellent written and oral communication skills, as well as strong teamwork and interpersonal skills.
• Expert in ELISA techniques, flow cytometry, cell culture, immunoassays, antibody purification, and mouse handling, including immunizations, spleen removals, hybridomas, etc.
• Full expertise in immunization strategies and characterization of biomolecules of interest.
• Needs to be driven, committed, self-initiating, with perseverance and a sense of urgency.
• Legally authorized to work in the US.

Job Location

San Diego, CA