Senior Principal Engineer - Solid Oral Drug Products

Neurocrine Continental; San Diego (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

Neurocrine Biosciences seeks a Principal Engineer, Pharmaceutical Development for solid oral drug products. Lead technical strategy from late-stage development through scale-up and process validation, partnering with MSAT and external CDMOs to ensure robust manufacturing processes.

The role emphasizes QbD, DoE, predictive modeling and strong regulatory support to advance programs toward commercialization with cross-functional collaboration.

Qualifications

• BS/BA in Chemistry, Biochemistry or Chemical Engineering.
• Experience in pharmaceutical development and process development.
• Strong writing and data interpretation for technical reports.

Responsibilities

• Serve as SME in process engineering for solid oral drug products.
• Design phase-appropriate processes (granulation, encapsulation, tablet coating).
• Identify process risks (FMEA) and propose robust strategies.
• Review experimental designs, analytical data and regulatory documentation.
• Mentor junior scientists and engineers in development best practices.
• Collaborate with Analytical Development, MSAT and CDMO partners.

Skills

Process engineering

Pharmaceutical development

Quality by Design

DoE

Regulatory submissions

Cross-functional collaboration

Education

BS/BA in Chemistry, Biochemistry, Chemical Engineering

Job description

Neurocrine Biosciences seeks a Principal Engineer, Pharmaceutical Development for solid oral drug products. Lead technical strategy from late-stage development through scale-up and process validation, partnering with MSAT and external CDMOs to ensure robust manufacturing processes.

The role emphasizes QbD, DoE, predictive modeling and strong regulatory support to advance programs toward commercialization with cross-functional collaboration.