Senior Payroll GL Accountant

Structure Therapeutics Inc.; South San Francisco (CA); On-site; USD 114,000 - 140,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401k match

Unlimited PTO

Paid holidays

Job summary

Structure Therapeutics Inc. in the San Francisco Bay Area is seeking a Senior Payroll/GL Accountant to own US payroll via ADP TotalSource, coordinate international payroll, and lead month-end close with accuracy and SOX compliance.

You will partner with Finance and HR to improve controls, ensure equity tax handling, balance sheet reconciliations, and timely external audit support; strong Excel and NetSuite experience is required. Base pay range: $114k-$140k.

Qualifications

• Bachelor's degree in Accounting, Finance, or Business Administration with an accounting concentration.
• 5+ years of accounting experience with payroll ownership.
• Hands-on experience with ADP TotalSource and NetSuite.
• Knowledge of multi-state payroll taxes and year-end reporting (W-2, 941).
• Experience with Equity Edge Online and equity reporting.
• US GAAP, month-end close, reconciliations, SOX compliance.
• Advanced Excel skills and cross-functional collaboration.

Responsibilities

• Payroll Processing: Own end-to-end semi-monthly payroll for US employees via ADP TotalSource and coordinate international payroll.
• Process off-cycle payroll and taxable events (RSU vesting, stock options, ESPP).
• Monitor payroll taxes, ensure withholding, reporting, and compliance.
• Strengthen internal controls to maintain SOX compliance.
• Prepare monthly payroll journal entries with detailed cost distribution.
• Reconcile payroll‑related balance sheet accounts and assist period-end close.
• Review expense report coding in Ramp before sync with NetSuite.
• Collaborate with Finance and HR to improve efficiency and accuracy.
• Support general ledger tasks and external audit preparations (PBC).

Skills

Advanced Excel

Excellent communication

Highly organized

Detail-oriented

Process improvement

Payroll ownership

Education

Bachelor's in Accounting

Tools

ADP TotalSource

NetSuite

Equity Edge Online

Ramp

Job description

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions. Structure Therapeutics is led by an experienced group of international drug innovators and financed by top‑tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary

We’re looking for a Senior Payroll/GL Accountant with strong expertise in Payroll and General Ledger (GL) operations to join our Finance team. In this role, you'll take full ownership of the payroll process, act as the primary point of contact for payroll and payroll tax matters and help streamline accounting operations. The ideal candidate brings hands‑on experience in ADP TotalSource and NetSuite, thrives in a fast‑paced, high‑growth environment, and is passionate about accuracy, compliance, and process excellence.

Job Responsibilities

• Payroll Processing: Own the end‑to‑end semi‑monthly payroll process for U.S.-based employees via ADP TotalSource, and coordinate payroll for our EMEA employees with an international payroll provider
• Process off‑cycle payroll, including taxable event reporting for equity transactions (e.g., RSU vesting, stock option exercises, ESPP)
• Monitor and resolve payroll tax issues, ensuring accurate withholding, reporting, and compliance across jurisdictions
• Strengthen internal controls surrounding the payroll process to maintain SOX compliance
• Journal Entries & Month‑end Close: Prepare monthly payroll journal entries, including detailed department and time allocation, ensuring accurate payroll cost distribution across the organization
• Contribute to the monthly period‑end close by reconciling payroll‑related balance sheet accounts and verifying accuracy and completeness
• Expense Review: Review employee expense report coding in Ramp prior to synchronization with NetSuite
• Accounting Operations & Collaboration: Partner with Finance and HR teams to support the payroll and monthly close process and implement efficiency and accuracy improvements
• Support general ledger tasks, such as preparing cash journal entries, bank account reconciliations, and others as needed
• Coordinate and provide PBC (Prepared by Client) documentation to external auditors in support of SOX testing, quarterly and annual financial audits

Qualifications

• Bachelor’s degree in Accounting, Finance, or Business Administration (with an accounting concentration)
• 5+ years of relevant accounting experience, with direct payroll ownership preferred
• Hands‑on experience with ADP TotalSource and NetSuite
• Strong knowledge of payroll tax regulations, including multi‑state withholding, equity compensation taxation, and year‑end reporting (e.g., W‑2, 941s)
• Experience with Equity Edge Online and understanding of equity reporting and related payroll tax withholding and compliance requirements
• Proficient in US GAAP and payroll accounting principles; Proven experience supporting month‑end close and account reconciliations
• Familiarity with SOX compliance
• Advanced Excel skills a must
• Highly organized, detail‑oriented, and proactive in identifying process improvements
• Excellent communication skills and ability to collaborate cross‑functionally

Travel Required

This position is primarily based in the San Francisco Bay Area and requires little to no travel. Travel may be required on an occasional basis for meetings, training, or company events.

Structure Therapeutics Inc. is an Equal‑Opportunity Employer. Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $114,000-$140,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance‑based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.