Senior Medical Director, Oncology Clinical Development – Sarcoma

Jobtailor

Massachusetts

On-site

USD 250,000 - 420,000

Full time

9 days ago

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Job summary

Jobtailor seeks a Senior Oncology Clinical Development leader to oversee medical oversight across study design, conduct, and data interpretation. You will guide safety monitoring, interpret complex data, and partner with cross-functional teams to drive programme delivery.

You will mentor Medical Directors, contribute to regulatory discussions, and lead oncology-wide initiatives. A medical degree with advanced oncology training and a track record in sarcoma/soft tissue cancers across Phase I–III

Qualifications

Medical degree with advanced specialty training in oncology or hematology.
Experience leading drug development in sarcoma oncology.
Clinical and pharmaceutical experience in oncology development across multiple studies.
Experience in medical monitoring, safety evaluation, and data interpretation across trials.
Understanding of GCP, ICH guidelines, and global regulatory frameworks.
Experience working in cross-functional matrix teams on complex decisions.
Deep expertise in soft tissue sarcoma and osteosarcoma across early to late-stage studies.
Strong scientific communication and stakeholder engagement skills.
Proven record in regulatory interactions (IND, NDA/MAA) and scientific collaborations.

Responsibilities

Provide medical oversight across study design, conduct, and data interpretation.
Lead medical monitoring and safety oversight across studies.
Interpret complex clinical and safety data to inform programme decisions.
Mentor Medical Directors and support capability development.
Contribute to regulatory discussions and health authority interactions.
Engage with investigators and KEEs at advisory boards and forums.
Lead or contribute to oncology clinical development initiatives and workstreams.
Support disease-area strategy and evidence planning across programmes.

Skills

Oncology Clinical Development

Medical Monitoring

Regulatory Interactions

Clinical Study Design

GCP/ICH Guidelines

Stakeholder Engagement

Leadership

Mentoring

Education

Medical Degree

Fellowship in Medical Oncology

Advanced Specialty Training

Job description

Responsibilities

Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation.
Provide guidance on medical monitoring and safety oversight across studies.
Interpret complex clinical and safety data to inform programme-level decisions led by the CDL.
Partner with the Senior Scientist and cross-functional teams across study execution and programme delivery.
Provide senior medical input into protocol development and study design.
Serve as a senior member of the Clinical Matrix Team, influencing study-level and programme-level decisions.
Engage with investigators, Key External Experts, and scientific leaders at advisory boards, steering committees, and scientific forums.
Mentor Medical Directors and support development of clinical capability.
Guide safety-data interpretation, signal detection, escalation, and benefit–risk evaluation.
Contribute to safety review forums such as SRT and IDMC.
Support resolution of complex medical questions during study conduct.
Interpret clinical data across studies and contribute to scientific communications, publications, congress materials, and clinical summaries.
Contribute to regulatory interactions and Health Authority discussions.
Lead or contribute to clinical and technical diligence for business development opportunities.
Contribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions.
Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams.
Contribute to talent development, performance discussions, and capability building.

Requirements

Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in medical oncology, pediatric oncology or hematology.
Experience in sarcoma oncology, including leading drug development.
Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes.
Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies.
Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks.
Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions.
Deep expertise in soft tissue sarcoma and osteosarcoma, including experience leading or supporting clinical development programs across early and/or late-stage clinical studies.
Strong scientific communication and stakeholder engagement skills.
Deep experience in oncology clinical development across multiple studies or programmes, including Phase I–III.
Experience contributing to or leading aspects of regulatory interactions (e.g., IND, scientific advice, NDA/MAA).
Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncology.
Track record of scientific publications and congress presentations.
Deep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignancies.
Experience contributing to clinical and technical diligence for business development opportunities.

Core Competencies

Demonstrates extensive expertise in Oncology Clinical Development, including medical oversight, safety evaluation, and clinical data interpretation. Proven ability to engage with stakeholders and contribute to regulatory interactions and scientific communications.

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