Senior Medical Director, Clinical Development, Neurosciences

APX Life Sciences; Boston (MA); Hybrid; USD 250,000 - 350,000; Full time

Job summary

APX Life Sciences in Boston is seeking a Senior Medical Director, Clinical Development to lead protocol design, execution, and medical review for neuropsychiatric trials. The role includes acting as Global Clinical Lead, guiding strategy, and mentoring junior scientists across Phase 2/3 programs.

The ideal candidate holds an MD with psychiatry experience, a track record in clinical development, and strong communication skills for senior leadership and external audiences.

Qualifications

• MD with clinical development experience in psychiatry.
• Experience across early and late-stage programs.
• Experience with global regulatory agencies and submissions.
• Excellent written and verbal communication, including leadership presentations.
• Ability to work effectively in a hybrid, matrixed environment.

Responsibilities

• Lead protocol design and execution for neuropsychiatric trials.
• Serve as Global Clinical Lead for programs.
• Author and review clinical and regulatory documents.
• Provide medical review and monitoring for Phase 2/3.
• Contribute to strategic development plans and portfolio direction.
• Mentor junior colleagues and clinical scientists.
• Represent organization to investigators and external partners.
• Collaborate with Clinical Operations to ensure timely study execution.

Skills

Protocol design

Global clinical lead

Medical review

Team leadership

Regulatory submissions

Stakeholder management

Cross-functional collaboration

Travel readiness

Hybrid work adaptability

Education

MD in Psychiatry

Job description

APX Life Science is partnering with a growing biopharmaceutical organization who are seeking to appoint a Senior Medical Director, Clinical Development to play a key leadership role in advancing therapies for neuropsychiatric disorders. This is a high‑visibility position with significant strategic and scientific impact across the clinical development portfolio.

Key Responsibilities

• Lead protocol design and execution for clinical trials in neuropsychiatric indications.
• Serve as Global Clinical Lead for one or more programs, guiding clinical strategy and subteam activities.
• Author and review clinical and regulatory documents, including protocols, CSRs, study documents, and submissions.
• Provide medical review and medical monitoring for Phase 2 and Phase 3 studies (in partnership with CRO medical monitors).
• Participate in strategic discussions on clinical development plans, indication prioritization, and portfolio direction.
• Mentor junior clinical development colleagues and clinical scientists as needed.
• Represent the organization to clinical investigators, external partners, and scientific/advocacy groups.
• Collaborate with Clinical Operations to ensure timely, high‑quality study execution aligned with budget and performance expectations.

Qualifications

• MD with clinical development experience in psychiatry.
• Clinical Development track record within the pharmaceutical/biotech industry experience.
• Experience across early and late‑stage clinical programs.
• Demonstrated ability to apply medical expertise to the development of new chemical entities (NCEs).
• Experience interacting with global regulatory agencies; prior involvement in successful submissions is highly valued.
• Excellent written and verbal communication skills, including presenting to senior leadership and external audiences.
• Strong leadership, collaboration, and ability to navigate complex, matrixed environments.
• Willingness to travel domestically and internationally (~25%).
• Ability to thrive in a hybrid work environment with regular on‑site collaboration.