Senior Materials Scientist Solid-State & bRo5 Formulations

LabRulez; Groton (CT); In loco; USD 100.000 - 140.000; Tempo pieno

Vantaggi offerti da questo lavoro

Full-time benefits

Medical, dental, and vision options

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Descrizione del lavoro

Eurofins USA PSS Insourcing Solutions in Groton, CT is seeking a Senior Scientist, Materials Development, specializing in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules including PROTACs, RIPTACs and molecular glues. The role focuses on advanced solid form screening, ASD formulations and predictive modeling.

The candidate will collaborate with Medicinal Chemistry, Formulation and Biopharmaceutics to align screening with clinical studies, perform solid-state

Competenze

• Master’s Degree with 2+ years of experience or a PhD in pharmaceutical science, chemistry, chemical engineering, or related field.
• Experience in pharmaceutical solid-state characterization techniques (such as X-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, spectroscopy, etc.). Strong data analysis and interpretation skills.
• Experience and understanding of infrared spectroscopy (FTIR, NIR, FT-Raman) and/or SSNMR.
• Experience with solving Materials Science problems related to large molecules, e.g., solid state chemistry and particle characterization using experimental approaches and team collaboration.
• Experience with amorphous solid dispersion strategies and ability to develop innovative solid form screening strategies.
• Understanding of physical, analytical, and organic chemistry.
• Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.
• Experience in mathematical modeling.

Mansioni

• Conduct advanced solid-state characterization of large bRo5 molecules of pharmaceutical relevance.
• Apply novel crystallization techniques to recrystallize bRo5 molecules.
• Support multidisciplinary project teams and collaborate with colleagues to define and implement crystallization, polymorph, salt, and co-crystal screening activities according to project timelines.
• Collaborate with colleagues in Medicinal Chemistry, Formulation and Biopharmaceutics to define and implement screening and characterization strategies consistent with solid form selection for clinical studies.
• Solve scientific problems using contemporary Materials Science experimental techniques.
• Contribute to the development of new scientific approaches and knowledge within the Materials Science organization.
• Ensure contemporaneous and accurate entries are made in the electronic laboratory notebook system according to accepted good practice.

Conoscenze

X-ray powder diffraction

Polarized light microscopy

Differential scanning calorimetry

Thermogravimetric analysis

FTIR

NIR

FT-Raman

Solid-state NMR

Amorphous solid dispersion

Mathematical modeling

Formazione

Master’s Degree in pharmaceutical science/chemistry/chemical engineering

PhD in pharmaceutical science/chemistry/chemical engineering

Descrizione del lavoro

Eurofins USA PSS Insourcing Solutions in Groton, CT is seeking a Senior Scientist, Materials Development, specializing in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules including PROTACs, RIPTACs and molecular glues. The role focuses on advanced solid form screening, ASD formulations and predictive modeling.

The candidate will collaborate with Medicinal Chemistry, Formulation and Biopharmaceutics to align screening with clinical studies, perform solid-state