Senior Manager, Clinical Data Enablement

USA - 3310 Takeda Pharmaceuticals U.S.A., Inc.; United States; Remote; USD 137,000 - 215,000; Full time

Job summary

Takeda is seeking a Senior Manager, Clinical Data Enablement to lead end-to-end clinical data pipelines across cloud-based lake/warehouse environments. This remote role reports to the Director, Clinical Data Engineering and partners with vendors and internal teams to ensure compliant, timely delivery of data products.

You will build scalable ETL/ELT capabilities on AWS/Azure, embed data integrity controls, and drive lifecycle documentation and audit readiness within a GxP-regulated environment.

Qualifications

• BS/BA plus 6+ years in data engineering and multi-source data integration.
• Strong SQL, data modeling, and data quality controls.
• Proficiency in Python; production pipelines; Jira/Confluence.
• Knowledge of CDISC, CDASH, and SDTM standards.
• Experience with CSV/JSON/XML and API/file integrations.
• Cloud platforms (AWS/Azure) and data warehouse/lake tech.
• Regulatory (GxP) environment; change control and audit readiness.
• Mentor junior engineers and collaborate across teams.

Responsibilities

• Own end-to-end clinical data pipelines across lake/warehouse environments.
• Build and scale cloud ETL/ELT capabilities for ingestion, transformation, orchestration, and delivery.
• Automate integrations and run operations with quality checks.
• Partner with vendors and cross-functional teams on data transfer specs and integration patterns.
• Ensure on-time, high-quality delivery and manage SLAs/OLAs.
• Design data engineering solutions with lifecycle documentation and audit-ready evidence.
• Embed data integrity controls and support validated operations.
• Collaborate with Quality/Compliance/IT for access controls and logging.

Skills

SQL

Data modeling

Python

ETL/ELT

GxP compliance

Jira/Confluence

Cloud AWS/Azure

Education

BS/BA (or equivalent)

Tools

Snowflake

Databricks

Amazon Redshift

CSV/JSON/XML

GitHub/GitLab

CI/CD

Job description

Job Description

Are you looking for a patient-focused, innovation-driven company to inspire you and empower you to shine? Join us as a Senior Manager, Clinical Data Enablement based remotely reporting to the Director, Clinical Data Engineering.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to work towards their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, and work toward excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to provide Better Health and a Brighter Future to people around the world.

Here, you will be a necessary contributor to our inspiring, bold mission.

GOALS:

The Senior Manager, Clinical Data Enablement is responsible for operating and continuously improving end-to-end clinical data pipelines across cloud-based data lake and data warehouse environments. This role builds scalable ingestion and transformation capabilities, partners closely with internal stakeholders and external vendors, and ensures reliable, compliant delivery of clinical data products to downstream consumers.

ACCOUNTABILITIES:

• Own end-to-end clinical data pipelines across lake/warehouse environments (build, run, monitor, maintain, troubleshoot) to ensure stable, performant, traceable operations.


• Drive operational excellence through monitoring/alerting, incident management, root-cause analysis, and corrective/preventive actions.


• Build and scale cloud ETL/ELT capabilities (AWS/Azure) for efficient ingestion, transformation, orchestration, and delivery.


• Automate integrations and run operations (scheduling, metadata-driven pipelines, automated quality checks) to improve reliability and timeliness.


• Partner with vendors and cross-functional teams to define data transfer specifications, acceptance criteria, and integration patterns; implement integrations with robust error handling and reconciliation.


• Serve as an SME for structured and unstructured data integration, driving continuous improvements through stakeholder feedback and evolving requirements.


• Partner with downstream teams (Stat Programming, SDTM, Analytics, Clinical Data Programming) to deliver fit-for-purpose datasets and interfaces (format, structure, cadence).


• Ensure on-time, high-quality delivery to agreed specifications; establish and manage SLAs/OLAs as needed.


• Design and deliver GxP-aligned clinical data engineering solutions with lifecycle documentation, traceability, and audit-ready evidence.


• Embed data integrity controls (e.g., ALCOA+) and support validated operations via change control, incident/deviation documentation, periodic review, and inspection readiness.


• Collaborate with Quality/Compliance/IT to implement appropriate access controls, logging/audit trails (as applicable), and operating controls.

EDUCATION AND EXPERIENCE:

• BS/BA (or equivalent) plus6+ yearsin data engineering, pipeline development/operations, and multi-source data integration (clinical/biopharma preferred).


• StrongSQL, data modeling, and data quality controls; working knowledge ofNoSQLand integration patterns.


• Proficiency inPython (preferred) or R; experience building production pipelines (testing, logging, monitoring); familiarity with SDLC practices;Jira/Confluence required.


• Knowledge of CDISC, CDASH, and SDTM standards preferred.


• Hands-on withCSV, JSON, XML, andAPI/file-basedintegrations.


• Cloud experience (e.g., AWS such as EC2/EMR/RDS/Redshift/Apache Spark) and related platforms (e.g., Snowflake, Databricks).Pipeline and platformexpertise: reusable ELT/ETL frameworks; data warehouse/data lake technologies(e.g.,Snowflake,Amazon Redshift); large-scale pipeline performance and maintenance.


• GitHub/GitLabversion control; CI/CD exposure preferred.


• Experience working inGxP-regulatedenvironments with change control/audit readiness expectations; ability to embeddata integritycontrols into pipelines and operations.


• Mentor junior engineers/FSPs; independent and collaborative problem-solving; ability to prioritize in a fast-paced environment and deliver to deadlines.


• Strong collaboration and communication; organized, self-directed, proactive problem-solver.


• Prior regulatory inspection experience preferred.


• AWS/Azure and/or Python certification preferred.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Massachusetts - Virtual

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Massachusetts - Virtual

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.