Senior Manager, Biostatistics

Eikon Therapeutics; Jersey City (NJ); On-site; USD 170,000 - 205,000; Full time

Benefits offered by this job

401k plan with company matching

Medical, dental, vision insurance

Mental health and wellness benefits

On-site daily lunch program

Job summary

Eikon Therapeutics seeks a Senior Manager, Biostatistics to lead statistical design, analysis, and strategy for clinical trials and experimental studies. You will collaborate with cross-functional teams to ensure robust evidence and regulatory readiness.

The role requires a PhD or equivalent with 3+ years in clinical research or a Master’s with 7+ years, strong R skills, oncology trial experience, and demonstrated leadership and communication across stakeholders.

Qualifications

• PhD or equivalent in statistics/biostatistics with clinical research/drug development experience; or a Master’s with substantial relevant work.
• Hands-on proficiency in R within Posit/RStudio ecosystem (R Markdown, Shiny, tidyverse)
• Extensive oncology trial experience and familiarity with RECIST endpoints and dose-escalation designs
• Independent ownership of full analysis lifecycle from raw data to output
• Strong regulatory understanding (ICH, FDA) and ability to author analysis plans and reports
• Experience with Bayesian statistics and adaptive trial designs
• Excellent communication and leadership skills; ability to guide statistical programmers and biostatisticians
• Contributions to peer-reviewed publications or conference abstracts in oncology

Responsibilities

• Design clinical trials and experiments with appropriate statistical methodologies
• Develop statistical analysis plans including endpoints, sample size, randomization, and methods
• Perform advanced analyses on complex datasets and interpret results
• Mentor biostatisticians and statistical programmers
• Contribute to regulatory submissions and prepare statistical sections
• Stay updated on emerging biostatistics trends and software
• Lead adoption of advanced statistical tools and software

Skills

Biostatistics

Clinical trial design

Regulatory knowledge

Statistical programming (R)

Communication

Leadership

Publications

Education

PhD in statistics/biostatistics

Master’s with 7+ years experience

Tools

R (Posit/RStudio)

R Markdown

Shiny

tidyverse

Job description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

We are seeking a skilled and highly motivated Senior Manager, Biostatistics to join our talented team. The successful candidate will contribute their statistical expertise and strategic thinking to the design, execution, and analysis of clinical trials and experimental studies. In collaboration with cross-functional teams, you will lead statistical efforts that facilitate evidence-based conclusions and guide our research and development initiatives.

About You

The ideal candidate for this role should possess a proven track record of designing and analyzing clinical trials and experimental studies, particularly within the biotechnology, pharmaceutical, or related industries. This candidate excels in leading interdisciplinary teams to design studies, developing statistical analysis plans, performing advanced statistical analyses, and providing guidance to team members. Their proficiency in statistical programming languages, understanding of regulatory guidelines, and excellent communication skills are essential for conveying complex statistical concepts to non-technical stakeholders. The ideal candidate also demonstrates leadership capabilities and a deep knowledge of emerging trends and best practices in biostatistics, statistical tools, and software.

What You’ll Do

• Collaborate with interdisciplinary teams to design clinical trials, experiments, and studies, ensuring appropriate statistical methodologies are employed.
• Lead the development of statistical analysis plans, including endpoints, sample size determination, randomization strategies, and statistical methodologies.
• Perform advanced statistical analyses on complex datasets, interpreting results and drawing actionable conclusions.
• Provide guidance and mentorship to biostatisticians and statistical programmers within the team.
• Contribute to regulatory submissions by providing statistical expertise and preparing relevant sections of documents.
• Stay current with emerging trends and best practices in biostatistics and their application in the biotechnology field.
• Drive the implementation and utilization of advanced statistical tools and software.

Qualifications:

• PhD or equivalent degree in statistics/biostatistics or related discipline with a minimum of 3 years of clinical research and drug development experience, or a Master’s degree with a minimum of 7 years relevant work experience.
• Deep, hands-on proficiency in R within the Posit/RStudio ecosystem (R Markdown, Shiny, tidyverse).
• Substantial oncology trial experience — familiarity with standard oncology designs and endpoints (RECIST, dose-escalation/optimization designs such as BOIN, biomarker-driven subgroup work).
• Demonstrated ability to independently own the full analysis lifecycle, from raw data through exploratory analysis to finished output.
• Strong understanding of regulatory guidelines (ICH, FDA, etc.) and experience authoring statistical analysis plans and reporting via tables, listings, and figures.
• Experience with Bayesian statistics and adaptive trial designs (e.g., BOIN-type dose-escalation, dose-optimization frameworks).
• Excellent communication skills, including translating statistical findings for non-technical stakeholders.
• Demonstrated leadership capabilities, including the ability to lead and mentor a team.
• Experience contributing statistical analysis to peer-reviewed clinical publications or conference presentations (e.g., trial results manuscripts, oncology conference abstracts and posters).

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

• 401k plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

The expected salary range for this role is $170,000 to $204,750 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

As set forth in Eikon Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.