Senior Manager, Analytical Development

Scorpion Therapeutics; Madison (WI); On-site; USD 150,000 - 210,000; Full time

Job summary

Arrowhead Pharmaceuticals in Verona, WI is seeking a senior leader to head a team of CMC analytical scientists responsible for method development, validation, and characterization of RNAi drug candidates. The role emphasizes GMP compliance, regulatory documentation, and collaboration across R&D, manufacturing, QA, and regulatory affairs to meet program milestones.

Candidates should have an advanced degree in chemistry with extensive industry experience in pharmaceutical analytics and team

Qualifications

• PhD in Chemistry or related field with extensive analytical experience.
• Senior experience: 5+ years for PhD, 7+ years for MS, 10+ years for BS.
• Proven expertise in pharmaceutical analytical instrumentation and drug development processes.

Responsibilities

• Lead a team of CMC analytical scientists and oversee project milestones.
• Serve as SME in analytical techniques and regulatory compliance.
• Oversee method development, validation, and documentation.
• Coordinate with R&D, manufacturing, QA, and regulatory teams to meet timelines.

Skills

Team leadership

CMC analytical development

Analytical method development

GMP/regulatory compliance

Cross-functional collaboration

Education

PhD in Chemistry or related field

Tools

HPLC/LC-MS

Analytical instrumentation

Job description

Role

Lead a team of CMC analytical scientists in developing and validating analytical methods for Arrowhead's RNAi-based drug candidates, focusing on drug substance and drug product characterization, impurity profiling, and supporting GLP toxicology and cGMP clinical materials.

Responsibilities

• Manage team performance and development
• Serve as SME in analytical techniques
• Oversee method development, validation, and documentation
• Ensure compliance with GMP and regulatory standards
• Collaborate across R&D, manufacturing, QA, and regulatory departments to meet project timelines and deliverables

Requirements

• B.S., M.S., or PhD in Chemistry or related field
• 5+ years (PhD), 7+ years (M.S.), or 10+ years (B.S.) of relevant experience
• Proven expertise in pharmaceutical analytical instrumentation and drug development processes

HighValue

Focus on CMC analytical development for RNAi therapeutics, regulatory documentation, GMP compliance, team leadership, and cross-functional collaboration.

Work setup

Full-time onsite in Verona, WI.