Senior Manager, AI and Data Science

Madrigal Pharmaceuticals; Conshohocken (Montgomery County); Hybrid; USD 163,000 - 200,000; Full time

Benefits offered by this job

Flexible paid time off

Medical, dental, and vision insurance

401(k) offerings with employer match

Job summary

Madrigal Pharmaceuticals is looking for a Senior Manager in AI and Data Science to spearhead the development of innovative AI models and solutions. This role demands strong technical skills in machine learning, collaboration across teams, and the ability to manage complex projects.

The ideal candidate will have extensive experience in data science, AI development, and communication in Healthcare settings. Competitive salary and comprehensive benefits are included.

Qualifications

• 7+ years of experience in data science and applied machine learning.
• 3+ years implementing and deploying machine learning or AI systems.
• 1+ year of hands-on agentic AI development using frameworks.

Responsibilities

• Lead end-to-end development of machine learning and AI models.
• Collaborate with data scientists and ML engineers.
• Design and deliver AI solutions that support business needs.

Skills

Machine Learning

AI Development

Python

Communication

Education

Master’s or Ph.D. in Computer Science, Data Science, Engineering, Statistics or related field

Tools

Databricks

PyTorch

Scikit-learn

Spark

SQL

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Job Title: Senior Manager, AI and Data Science

Department: AI and Data Science

Location: Hybrid, Conshohocken PA

Job Description

We are expanding our AI capabilities to accelerate insights, enhance decision quality, and enable scalable innovation across the organization. We are seeking a Senior Manager, AI and Data Science who brings strong technical depth, hands‑on experience with agentic AI, and an ownership mindset. This individual will develop advanced AI solutions, partner across functions, and help expand our use of modern machine learning and agentic frameworks to support our mission.

Key Responsibilities

AI & Data Science Development

• Lead end‑to‑end development of machine learning and AI models, from problem framing through deployment and ongoing evaluation.
• Collaborate effectively with data scientists, ML engineers, and cross‑functional partners to design and deliver AI solutions that support business and scientific needs.
• Work with stakeholders to identify high‑value opportunities for AI that enhance Commercial, Medical, and enterprise‑level processes.

Agentic AI & Framework Integration

• Build and optimize AI agents and orchestration workflows using modern agentic frameworks such as LangGraph, LlamaIndex, or CrewAI.
• Develop modular and reusable components for reasoning, retrieval, tool integration, and workflow automation.
• Develop end‑to‑end agentic frameworks incorporating agent connectors, MCP tools, and integrated interfaces, working closely with the Agentic UI team to ensure seamless product delivery.

Modeling & Applied Machine Learning

• Design and deploy machine learning models, including applications in recommendation, personalization, and other ML‑driven decision‑support systems.
• Apply modern ML techniques, including embeddings, graph methods, and generative model integration to real‑world healthcare and Commercial challenges.
• Build AI solutions for Commercial use cases in Healthcare and Life Sciences.

Data Integration & MLOps

• Partner with data engineering teams to ensure scalable, ML‑ready data pipelines and model monitoring.
• Utilize platforms such as Databricks to support model development, optimization, and operationalization.

Cross‑Functional Engagement

• Translate complex AI concepts into clear, actionable insights for technical and non‑technical partners.
• Align AI initiatives with enterprise governance, privacy, and compliance expectations.

Qualifications

Required

• Master’s or Ph.D. in Computer Science, Data Science, Engineering, Statistics, or related field.
• 7+ years of experience in data science and applied machine learning.
• 3+ years implementing and deploying machine learning or AI systems in production environments.
• 1+ year of hands‑on agentic AI development using frameworks such as LangGraph, LlamaIndex, or CrewAI.
• Experience working with patient‑level data and feature engineering.
• Experience building recommender systems or related ML approaches.
• Proficiency in Python, ML frameworks (PyTorch, Scikit‑learn, MLflow), and data tools (Spark, SQL).
• Demonstrated ability to work collaboratively across scientific, technical, and business teams.
• Strong communication skills with the ability to convey complex concepts clearly.
• Experience in Healthcare or Life Sciences.

Preferred

• Familiarity with Databricks and modern cloud‑based ML development.
• Experience deploying Agents to production environments.
• Proven track record of building AI solutions in Healthcare and Life Sciences.

Total Rewards

Our Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Base salary for this position ranges from $163,000 to $200,000 per year, depending on qualifications, skills, education, experience, business needs and market demand. All employees receive equity, reinforcing an ownership culture. We comply with all applicable minimum wage laws.

Benefits

Full‑time employees receive comprehensive benefits, including flexible paid time off, medical, dental, vision, and life/disability insurance, and 401(k) offerings (traditional, Roth, and employer match). Additional voluntary benefits such as supplemental life insurance, legal services, and other offerings are available. Mental health benefits are provided through our Employee Assistance Program for employees and their families.

Equal Opportunity Employer

We are an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristics protected by applicable federal, state, or local law.

Reasonable Accommodations

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [e-mail].