Senior Engineer - Biomedical Systems

e184; Portland (OR); On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

Equity participation

Portland facility

Medical, Dental, Vision, and 401(k)

20 days PTO + 11 paid holidays

Job summary

e184 is seeking a Senior Engineer to lead the design and development of software systems that integrate and control experimental hardware for ex utero gestation. You will build intuitive interfaces unifying perfusion, imaging, environmental controls, and monitoring into a cohesive platform, with emphasis on reliability and safety.

You will own software development from interface design through system integration and deployment, collaborating with engineers, biologists, and hardware teams to

Qualifications

• 5+ years of professional software engineering experience spanning UI/UX, real-time systems, and/or controls engineering.
• Strong experience designing and implementing complex user interfaces for technical or scientific applications.
• Proficiency in modern frontend frameworks (e.g., React, Vue, or similar).
• Experience interfacing software with hardware systems, sensors, or laboratory instrumentation.
• Experience designing systems for real-time monitoring or device control.
• Experience designing closed-loop or feedback control systems (e.g., PID, model-based, or adaptive control) for physical or biological processes.
• Experience designing data acquisition pipelines and database infrastructure for continuous sensor or time-series data.
• Strong understanding of software architecture and maintainable system design.
• Ability to independently drive software projects from concept through deployment.
• Strong collaboration and communication skills in interdisciplinary environments.
• Comfort working in a fast-paced, iterative startup environment.

Responsibilities

• Design unified control interfaces for monitoring and control of perfusion, imaging, and environmental systems on-site and remotely.
• Integrate and automate experimental hardware, devices, and environmental controllers across the platform.
• Develop closed-loop perfusion control to regulate flow, pressure, oxygenation, and temperature.
• Develop real-time monitoring and data infrastructure with dashboards and data pipelines.
• Implement experiment automation and scheduling for reproducible system operation.
• Ensure system reliability and safety with fault detection and recovery mechanisms.
• Collaborate across disciplines to translate experimental needs into software architecture and contribute to code, docs, and testing practices.

Skills

UI/UX design

Real-time systems

Controls engineering

Frontend frameworks

Hardware interfacing

Data acquisition pipelines

Software architecture

Project delivery

Collaboration

Startup environment

Tools

React

Vue

MQTT

Serial/USB

TCP/IP

Job description

About us

e184 is a biotechnology research company dedicated to overcoming the limits of human biology. One of our programs in reproductive technologies develops ectogenesis - the ability to support human development outside the body - to expand reproductive freedom and redefine what is possible in medicine. Ourmission is to remove the biological constraints that limit who can safely carry a pregnancy, enabling new pathways to parenthood for individuals facing medical risk, infertility, or physiological barriers to gestation.

We operate at the intersection of biology, engineering, and computational science, building integrated platforms that combine advanced tissue models, adaptive culture systems, and automated experimental workflows to understand and recreate the conditions required for healthy human gestation beyond the uterus.

Role overview

As a Senior Engineer at e184, you will lead the design and development of software systems that integrate and control the experimental hardware enabling ex utero gestation. Your work will focus on building intuitive, reliable interfaces that unify perfusion systems, continuous imaging platforms, environmental controls, and monitoring infrastructure into a cohesive operational platform. This includes the control logic, feedback loops, and data infrastructure that keep automated perfusion, fluid management, and environmental systems running reliably over multi-week experiments, not just the interfaces researchers use to monitor them.

You will own software development from interface design through system integration and deployment, working closely with engineers, biologists, and hardware teams to translate complex experimental workflows into robust, user-centered control systems. This is a highly hands‑on role for an engineer who enjoys bridging UI design, real‑time control systems, and scientific experimentation in a fast‑moving startup environment where software reliability directly impacts biological outcomes.

What you'll do:

• Design unified control interfaces: Build the interfaces researchers use to monitor and control perfusion, imaging, and environmental systems from a single platform, on-site and remotely.

• Integrate and automate experimental hardware: Build software that communicates with pumps, sensors, imaging devices, and environmental controllers, and automates fluid, reagent, and waste management across the platform.

• Develop closed‑loop perfusion control: Design control systems that regulate flow, pressure, oxygenation, and temperature against physiological targets, evolving toward predictive, adaptive optimization as experimental data accumulates.

• Develop real‑time monitoring and data infrastructure: Build dashboards and the underlying data pipelines that capture, store, and surface sensor and experimental data from long‑running runs.

• Implement experiment automation and scheduling: Design workflows that support automated protocols and reproducible system operation.

• Ensure system reliability and safety: Build fault detection, error handling, and recovery mechanisms that keep long‑duration experiments stable.

• Collaborate across disciplines and establish software standards: Work with hardware engineers and scientists to translate experimental needs into software architecture, and contribute to code, documentation, and testing practices that scale.

Core requirements:

• 5+ years of professional software engineering experience spanning UI/UX, real‑time systems, and/or controls engineering

• Strong experience designing and implementing complex user interfaces for technical or scientific applications

• Proficiency in modern frontend frameworks (e.g., React, Vue, or similar)

• Experience interfacing software with hardware systems, sensors, or laboratory instrumentation

• Experience designing systems for real‑time monitoring or device control

• Experience designing closed‑loop or feedback control systems (e.g., PID, model‑based, or adaptive control) for physical or biological processes

• Experience designing data acquisition pipelines and database infrastructure for continuous sensor or time‑series data

• Strong understanding of software architecture and maintainable system design

• Ability to independently drive software projects from concept through deployment

• Strong collaboration and communication skills in interdisciplinary environments

• Comfort working in a fast‑paced, iterative startup environment

You’ll stand out with:

• Experience developing software for laboratory automation, robotics, medical devices, or scientific instrumentation

• Experience integrating imaging systems or real‑time data streams

• Familiarity with control systems, hardware communication protocols (e.g., serial, USB, TCP/IP, MQTT)

• Experience building data visualization dashboards for live experimental monitoring

• Experience designing safety‑critical or long‑running control systems

• Experience with model predictive control (MPC), adaptive control, or applied machine learning for process optimization or anomaly detection

• Experience with time‑series databases (e.g., InfluxDB, TimescaleDB) for continuous experimental monitoring

• Prior startup or early‑stage technology development experience

Why e184?

• Unrivaled impact: Your work directly enables technology that transforms human fertility and reproductive medicine.

• Full‑spectrum growth: Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.

• Best of both worlds: Experience the creative chaos of an early‑stage startup with the stability of a well‑capitalized company.

• Elite collaboration: Work alongside a world‑class team who are as driven as you are.

The perks

• Competitive salary + equity participation is considered

• State‑of‑the‑art facility in Portland metro area

• Comprehensive Medical, Dental, Vision, and 401(k) with company match

• 20 days PTO + 11 paid holidays

Disclaimer

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.