Senior Electrical Engineer, PCB Systems

Flagship Pioneering; Cambridge (ME); On-site; USD 140,000 - 210,000; Full time

Job summary

Tilde Bio, Inc. is seeking a Senior Electrical Engineer with deep PCB design expertise to join our multidisciplinary engineering team and support a next-generation proteomics platform.

You will lead multilayer PCB design, address signal and power integrity, and collaborate with firmware, mechanical, and system teams from concept through production.

The role requires 7+ years in the industry, strong communication, and a hands-on approach to bring hardware from prototype through manufacturing.

Qualifications

• 7+ years in PCB design and hardware development.
• Multilayer PCB design experience for mixed-signal/high-speed systems.
• Experience with high-speed interfaces: USB, Ethernet, PCIe, DDR, SPI, I2C.
• Knowledge of signal integrity, power integrity, grounding, EMI/EMC.
• Hands-on board bring-up, debugging, and lab instrumentation.

Responsibilities

• Lead design and development of complex, multilayer PCBs.
• Architect mixed-signal, high-speed, low-noise circuits.
• Collaborate with SW/HW engineers and vendors for integration.
• Create documentation: schematics, layouts, validation reports.
• Drive DFM and DFT best practices.
• Contribute to IP and technical strategy.

Skills

PCB design

Hardware development

Signal integrity

Lab instrumentation

Problem solving

Communication

Education

Electrical Engineering degree

Tools

HDI design

FPGA

Job description

About Tilde (FL110)

Tilde Bio, Inc. (FL110) is building a next-generation biological sensing platform at the intersection of synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. Our goal is to create programmable biological measurement systems capable of extracting rich molecular information from single-molecule interactions.

We believe nanopores generate a high-dimensional measurement of molecular identity and behavior that remains largely untapped. Unlocking that information requires new computational approaches --- ones that don't yet exist --- built by people who are comfortable working at the edge of what's known. At Tilde, you will work alongside scientists and engineers from diverse disciplines to help define how a new generation of biological sensing systems extract meaning from the physical world.

Tilde is backed by Flagship Pioneering, which brings the long-term vision and resources needed to build platforms that don't fit neatly into existing categories.

Position Summary

We are seeking a highly motivated and experienced Senior Electrical Engineer with deep expertise in printed circuit board (PCB) design and development to join our multidisciplinary engineering team. This individual will play a critical role in the design, layout, integration, and validation of complex PCBs that support our next-generation proteomics platform.

The ideal candidate will have strong experience in mixed-signal and high-speed PCB design, signal integrity, power integrity, and system-level integration. This role requires close collaboration with firmware, mechanical, bioengineering, and systems teams to deliver robust, manufacturable, and high-performance hardware solutions from concept through production.

Key Responsibilities

• Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems.
• Architect mixed-signal, high-speed, and low-noise circuit designs including analog front ends, power management, data acquisition, and embedded processing systems.
• Collaborate with SW and HW engineers as well as external vendors to ensure seamless hardware--software integration and instrument development.
• Develop and maintain comprehensive documentation including schematics, layout files, validation reports, and specifications.
• Drive design reviews, design for manufacturability (DFM), and design for testability (DFT) best practices.
• Contribute to intellectual property generation and technical strategy discussions.

Basic Qualifications

• B.S., M.S., or Ph.D. in Electrical Engineering or a related field.
• Minimum of 7 years of industry experience in PCB design and hardware development.
• Demonstrated expertise in multilayer PCB design for mixed-signal or high-speed systems.
• Experience with high-speed interfaces (e.g., USB, Ethernet, PCIe, DDR, SPI, I2C).
• Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
• Hands‑on experience with board bring‑up, debugging, and lab instrumentation (oscilloscopes, logic analyzers, spectrum analyzers).
• Experience taking products from prototype through manufacturing.
• Strong problem‑solving skills and ability to operate effectively in a fast‑paced, evolving environment.
• Excellent written and verbal communication skills.

Nice‑to‑Haves

• Experience designing electronics for scientific instrumentation, medical devices, or life sciences platforms.
• Familiarity with FPGA‑based systems and embedded processors.
• Experience with high‑density interconnect (HDI) design and fine‑pitch components.
• Knowledge of regulatory compliance standards (e.g., CE, FCC, IEC).
• Experience working in early‑stage or startup environments.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

About Flagship Pioneering

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more at www.flagshippioneering.com

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status

Recruitment & Staffing Agencies

Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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