Senior Director, Quality Control

Nurix Therapeutics; Brisbane (CA); On-site; USD 280,000 - 320,000; Full time

Job summary

Nurix Therapeutics seeks an experienced Senior Director, Quality Control to establish and lead a QC organization supporting programs from CMC development to commercial manufacturing.

The role requires building a capable team, defining QC strategy, managing external collaborations with CDMOs/CTLs, and ensuring GMP-compliant operations across the product lifecycle.

Qualifications

• Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline.
• 16+ years (BS/MS) or 14+ years (PhD) of relevant experience.
• 5+ years in a QC leadership or management role.
• External manufacturing and testing operations at CDMOs and CTLs experience.
• Expertise with analytical methods including HPLC, GC, dissolution, and microbiological testing.
• Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards.
• Experience contributing to global regulatory filings and health authority responses.
• Strong interpersonal and cross-functional collaboration skills across Quality, Supply Chain, Analytical Development, and Manufacturing.

Responsibilities

• Build and lead the QC function: establish systems, recruit and mentor staff and contractors.
• Set QC strategy across the product lifecycle from CMC development to commercial programs.
• Oversee QC operations at internal sites and with CDMOs/CTLs, including validation, release, and stability testing.
• Identify and manage quality risks related to patient safety, product quality, shelf life, and GMP compliance.
• Lead QC during health authority inspections and internal site audits.
• Support regulatory submissions and health authority interactions.
• Direct stability programs aligned with ICH guidelines and regional requirements.
• Manage reference materials and sample retentions; oversee qualification/inventory.
• Drive continuous improvement, data integrity and eQMS upgrades for a scalable QC organization.
• Travel up to 15% to CDMOs, CTLs, and conferences.

Skills

QC leadership

Team mentorship

Analytical mindset

Cross-functional collaboration

Regulatory alignment

Education

Advanced degree in Chemistry/Pharmaceutics/Chemical Engineering

BS/MS with 16+ years or PhD with 14+ years

Tools

HPLC

GC

Dissolution

Microbiological testing

Job description

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix Therapeutics is seeking an experienced Senior Director, Quality Control to join the Analytical Development and Quality Control group. This individual will establish and lead a QC operational function, establishing operations, systems, and a team to support programs from CMC development through commercial manufacturing.

Key Responsibilities

• Build and lead the QC function: Establish QC systems and infrastructure; recruit, manage, and mentor internal QC staff and contractors
• Set QC strategy across the product lifecycle: Define and execute QC strategy spanning CMC development through commercial programs, ensuring alignment with company milestones and submission timelines
• Oversee QC operations internally and externally: Direct method validation, release and stability testing, data review, deviations, investigations, change control, and CAPA internally and at CDMOs, and CTLs
• Identify and manage quality risk: Proactively identify, assess, and elevate risks related to patient safety, product quality, shelf life, supply continuity, or GMP compliance; drive risk mitigation strategies in partnership with Analytical Development, Quality, and Manufacturing functions
• Lead QC through audits and inspections: Serve as QC lead during health authority inspections and internal audits; collaborate with Quality to conduct audits of GMP manufacturing and testing sites, including CDMOs and CTLs
• Support regulatory submissions and health authority interactions: Contribute to global regulatory filings; collaborate on responses to health authority information requests, regulatory commitments, and post-approval changes
• Direct stability programs: Develop and execute stability strategy in collaboration with Analytical Development leads, ensuring alignment with ICH guidelines and regional regulatory requirements
• Manage reference materials and retains: Oversee qualification and inventory of reference standards; develop sampling plans and manage sample retain programs
• Drive continuous improvement: Identify and implement process improvements, data integrity enhancements, and quality system upgrades (e.g., eQMS) to support a scalable, inspection-ready QC organization
• Travel up to 15% to CDMO, CTL, and manufacturing sites and supplier and scientific conferences

Qualifications

• Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline. BS/MS with 16+ years of relevant experience, or PhD with 14+ years of relevant experience
• 5+ years in a QC leadership or management role, with demonstrated ability to build and mentor teams
• Deep experience in small molecule pharmaceutical development, including method lifecycle management and oversight of validation, release, and stability operations
• Proven experience managing external manufacturing and testing operations at CDMOs and CTLs
• Expertise with analytical methods such as HPLC, GC, dissolution, and microbiological testing
• Direct experience leading through health authority inspections and internal audits and conducting audits of manufacturing and testing sites.
• Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards
• Experience contributing to global regulatory filings and health authority correspondence (e.g., responses to information requests, post-approval changes)
• Strong interpersonal and cross-functional collaboration skills, with the ability to influence and build consensus across Quality, Supply Chain, Analytical Development, and Manufacturing functions

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:

$280,200 - $319,800

Location:

Woodlands TX or Brisbane, CA - Onsite