Senior Director, Portfolio Integration Lead

GlaxoSmithKline; United States; Hybrid; USD 242,000 - 404,000; Full time

Job summary

GlaxoSmithKline is seeking a Senior Director, Portfolio Integration Lead to guide oncology program strategy and cross‑portfolio execution. The role emphasizes biomarker strategies, disease biology, and innovative trial designs to accelerate cancer therapies.

Ideal candidates bring 10+ years in oncology drug development, with experience in cross‑functional matrix environments and external engagement. Hybrid work model, with on‑site and remote collaboration across US sites.

Qualifications

• 10+ years of experience in oncology drug development across multiple programs.
• Experience in clinical development processes, regulatory pathways, and oncology landscapes.
• Experience operating structured matrix organizations and stakeholder engagement at senior levels.

Responsibilities

• Provide senior scientific partnership to CDLs across assets (disease biology, biomarkers, combo strategies).
• Shape portfolio strategy and ensure cross‑program alignment and governance.
• Drive data, analytics and AI-enabled innovation in trials and portfolio decisions.

Skills

Oncology drug development

Matrix organization experience

Stakeholder engagement

AI/ML in clinical trials

Biomarker development

Education

Scientific or medical degree

Job description

Job Title: Senior Director, Portfolio Integration Lead

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most – advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

In This Role You Will:

• Provide senior scientific partnership to CDLs, particularly in areas such as disease biology, biomarker strategy, and novel treatment combinations development.
• Ensure consistent cross-programme ways of working to improve development efficiency and execution.
• Drive cross-programme portfolio working groups and ensure business level alignment
• Drive and support clinical trial innovation based on evolving oncology treatment landscape, government regulations, basic/translational science, and emerging technologies (such as AI-enabled tools).
• Strengthen the scientific and strategic positioning of a pan-asset portfolio across multiple clinical and pre‑clinical assets.
• Drive initiatives that advance data and technology strategies supporting development decision‑making.
• Shape engagement with external experts and governance bodies including advisory boards where relevant.

Key Responsibilities

Portfolio Strategy & Cross-Program Integration

• Shape the advancement of multiple development programs within the oncology portfolio by providing scientific insights across assets, ensuring that agreed disease strategy is implemented consistently across programs.
• Prepare detailed strategic analyses and portfolio recommendations on behalf of the Disease Area Vice President, enabling effective decision‑making at senior leadership and governance levels.
• Ensure alignment and coordination across Clinical Matrix Teams (CMTs) and relevant cross‑functional stakeholders in Research & Development (R&D), Global Medical Affairs (GMA) and Global Product Strategy (GPS).
• Drive disease-level strategic discussions and portfolio planning, bringing a pan‑asset perspective to governance discussions and portfolio prioritization.
• Serve as a subject matter expert supporting global health authority interactions, regulatory submissions and key development milestones across multiple assets.

Partnership with Clinical Development Leads

• Serve as a scientific thought partner to CDLs across multiple asset programs, shaping key aspects of clinical development strategy for a given tumour types, including:
• disease biology and translational science
• biomarker and precision medicine approaches
• combination strategies
• emerging clinical development opportunities

Clinical Development Excellence

• Establish and champion consistent ways of working across programs to improve efficiency and development quality.
• Drive innovation in clinical development approaches for a given disease area, including trial design, novel endpoints, and emerging technologies such as AI-enabled analytics where appropriate.

External Scientific Engagement

• Maintain a deep understanding of the evolving tumour disease landscape, standards of care, and emerging science.
• Shape engagement with external experts through advisory boards.
• Synthesise portfolio-level external insights to inform and strengthen development strategy across multiple programs.

Data & Innovation Strategy

• Drive initiatives that strengthen the application of data, technology, and analytics in clinical development decision‑making for a given tumour type.
• Champion innovative approaches to clinical trials and portfolio insights, ensuring the tumour portfolio remains at the forefront of emerging capabilities.

Basic Qualifications

• Bachelor's / Master's / Advanced degree in a scientific or medical discipline. Candidates may come from a medical or scientific background; oncology drug development expertise with defined experience is expected.
• 10+ years of experience in oncology drug development within pharmaceutical or biotechnology environments, including involvement across multiple programs or assets.
• Experience of clinical development processes, regulatory pathways, and oncology therapeutic landscapes.
• Experience in operating structured matrix organizations and demonstrate decision‑making and stakeholder engagement at senior organizational levels.

Preferred Qualifications

• Experience as a Clinical Development Lead, Medical Director, Clinical Scientist Program Lead, or equivalent program leadership role in oncology.
• Expertise in biomarker development, precision medicine strategies, or combination therapy approaches.
• Experience engaging with external scientific experts, advisory groups, and Health Authorities.
• Demonstrated ability to influence senior stakeholders and shape strategic portfolio discussions.
• Familiarity with clinical trial innovation methods, including AI/ML applications, adaptive trial designs, or real‑world evidence integration.

Work Arrangement

This role offers a hybrid working model, with a mix of on‑site and remote work. Remote or fully home‑working arrangements are not available for this role.

If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $242,250 to $403,750.

If you are based in another US location, the annual base salary range is $242,250 to $403,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role.

In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

If you require an accommodation or other assistance to apply for a job at GSK/ViiV Healthcare, please submit a request to HR via the Service Portal

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

This Position Description is to provide a framework for job understanding between employee and manager. It may not cover or contain the full listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice and at the discretion of the management of the Company. The position description is not used in the assignment or assessment of any GSK level or grade used in the Job Evaluation Process.

Compensation Grade:

4

Job Posting End Date:

19-06-2026

Eligible for Employee Referral Bonus:

No