Senior Director, Medical Safety & Pharmacovigilance

Cytokinetics; California; On-site; USD 351,000 - 410,000; Full time

Benefits offered by this job

Stock options

Benefits

Wellness stipends

Job summary

Cytokinetics is seeking a Senior Director, Medical Safety & Pharmacovigilance to drive global safety strategy for investigational and marketed cardiovascular therapies. You will oversee safety surveillance, risk assessment, and pharmacovigilance governance across regions, partnering with Clinical Development, Regulatory, and Medical Affairs.

Based in South San Francisco, CA, the role offers stock options, benefits, and wellness stipends as part of total compensation.

Qualifications

• MD or equivalent (MD/PhD/MPH).
• 12+ years in pharma with pharmacovigilance and drug safety leadership experience.
• Deep knowledge of global PV regulations.
• Proven track record in safety surveillance, signal detection, and risk management.
• Strong scientific judgment, leadership, and communication skills.

Responsibilities

• Lead safety surveillance, signal detection, and risk assessment.
• Develop pharmacovigilance policies.
• Ensure compliance with global regulations (FDA, EMA, ICH).
• Oversee safety reporting, safety data review, and safety governance.
• Collaborate with cross-functional teams including Clinical Development, Regulatory, Medical Affairs, and external partners.
• Lead safety teams and manage inspection readiness.
• Contribute to regulatory submissions and safety documents.
• Monitor industry trends and evolving safety standards.
• Mentor safety staff and support corporate development activities.

Skills

Safety surveillance

Signal detection

Risk assessment

Leadership

Communication skills

Education

MD or equivalent (MD/PhD/MPH)

Job description

Role

Senior Director, Medical Safety & Pharmacovigilance at Cytokinetics, overseeing global safety strategy and risk management for investigational and marketed cardiovascular therapies.

Responsibilities

• lead safety surveillance, signal detection, and risk assessment
• develop pharmacovigilance policies
• ensure compliance with global regulations (FDA, EMA, ICH)
• oversee safety reporting, safety data review, and safety governance
• collaborate with cross-functional teams including Clinical Development, Regulatory, Medical Affairs, and external partners
• lead safety teams and manage inspection readiness
• contribute to regulatory submissions and safety documents
• monitor industry trends and evolving safety standards
• mentor safety staff and support corporate development activities

Qualifications

• MD or equivalent (MD/PhD/MPH)
• 12+ years in pharma, with extensive pharmacovigilance and drug safety leadership experience
• deep knowledge of global PV regulations
• proven track record in safety surveillance, signal detection, and risk management
• strong scientific judgment, leadership, and communication skills

High-Value

• Cardiovascular therapeutic area
• drug safety leadership
• global regulatory compliance
• investigation of safety data
• cross-functional collaboration
• team leadership
• regulatory reporting
• safety documentation
• industry trend monitoring

WorkSetup

Based in South San Francisco, CA, with salary range $351,180-$409,710.

• total compensation includes stock options, benefits, and wellness stipends