Senior Director, Gene Therapy Discovery & Translational

Solid Biosciences Inc.; Northern (KY); Hybrid; USD 260,000 - 305,000; Full time

Benefits offered by this job

Health & Dental

401(k) plan

Employee Stock Purchase Plan

Lunch on-site

On-site gym

15 days PTO

On-site parking

Job summary

Solid Biosciences is seeking a Senior Director, Discovery & Translational Development to lead a team of scientific program leads and translate cutting-edge science into disciplined development plans. The role partners with senior leaders to drive portfolio strategy and IND-enabling efforts.

The candidate will oversee translational strategies across Friedreich’s ataxia, CPVT, and genetic cardiomyopathy programs, and ensure regulatory readiness while maintaining a strong, collaborative culture at

Qualifications

• Leadership of scientific programs and teams in biotech/pharma
• Strategic thinking to shape portfolio and development plans
• Clear and impactful scientific communication to executives
• Mentoring and developing scientific leaders
• Experience leading cross-functional program teams
• Proven ability to drive decisions in ambiguous environments
• Experience with IND-enabling development and regulatory interactions

Responsibilities

• Lead and manage multiple discovery and translational development programs from concept to IND-enabling readiness
• Provide scientific and strategic leadership across rare neuromuscular and cardiac genetic diseases
• Partner with scientific leads to define hypotheses, strategies, and development plans
• Drive program progression with go/no-go criteria, risk assessment, and milestones
• Align translational strategies with clinical development, regulatory, CMC, and portfolio priorities
• Translate early opportunities into development-ready programs with clear rationale and plans
• Oversee clinical assay and biomarker strategies across programs
• Serve as a senior DTD representative in cross-functional governance and executive discussions
• Develop narratives for senior leadership and governance forums
• Represent DTD with external collaborators and strategic partners
• Contribute to IND-enabling strategy, regulatory documentation, and study reports

Skills

Leadership

Strategic thinking

Communication

Mentoring

Cross-functional collaboration

People management

Education

PhD/MD or equivalent

Job description

Solid Biosciences is seeking a Senior Director, Discovery & Translational Development to lead a team of scientific program leads and translate cutting-edge science into disciplined development plans. The role partners with senior leaders to drive portfolio strategy and IND-enabling efforts.

The candidate will oversee translational strategies across Friedreich’s ataxia, CPVT, and genetic cardiomyopathy programs, and ensure regulatory readiness while maintaining a strong, collaborative culture at