Senior Director, DMPK Project Leader

100 Eli Lilly and Company; United States; Remote; USD 177,000 - 339,000; Full time

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Flexible benefits

Life insurance

Time off & leave

Well-being benefits

Job summary

Eli Lilly and Company is seeking a Senior Director, DMPK Project Lead in the United States. The role ensures delivery of all DMPK activities, including nonclinical PK, in vitro ADME, biotransformation studies, and toxicokinetic analysis, enabling progression of CNS drug candidates through development.

The candidate will lead cross-functional teams, manage NDA submissions, and drive project strategies with urgency and scientific clarity across discovery and development stages.

Qualifications

• Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field.
• Experience leading DMPK programs and NDA submissions.

Responsibilities

• Lead the filing of NDAs for DMPK.
• Deliver high-quality DMPK input and data to projects within established timelines.
• Utilize knowledge of DMPK to support project strategy and progression.
• Proactively calculate PK and toxicokinetic parameters and report results to project teams.
• Coordinate with DMPK colleagues, clinical pharmacologists, and toxicologists.
• Prepare clear governance presentations related to DMPK findings.

Skills

DMPK expertise

PK modeling

NDAs regulatory submissions

Cross-functional leadership

Scientific communication

GLP studies

PK parameter estimation

Education

Ph.D. in Pharmaceutical Sciences/Pharmacology or related field

Tools

Phoenix WinNonlin

NCA PK modeling tools

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.

Description of Role Senior Director, DMPK Project Leader ensures delivery of all DMPK related activities working collaboratively as part of a cross-functional program team. These include nonclinical PK experiments, in vitro ADME, biotransformation studies,bioanalyticaland toxicokinetic analysis. This role supports understanding pharmacokinetic, toxicokinetic, and ADME principles to enable progression of drug candidates across the portfolio.A qualified candidate will havepreviousexperience in PK modeling ideally for CNS drug candidates and a basic understanding of vital ADME properties for CNS drug candidate progression. Furthermore, a qualified candidate will have end-to-end experience in drug discovery and development including NDA submission; will be able to partner with both discovery and development teams to enable the identification of lead candidates withoptimalDMPK properties for progression into nonclinical development and the progression of lead candidates into clinical development.

Key Responsibilities

• Lead the filing of NDAs for DMPK
• Deliver high-quality DMPK input and data to projects within established timelines
• Utilize knowledge of DMPK to support/influence compound profiling, project progression and project strategy
• Proactively calculate PK and toxicokinetic parameters, estimate safety margins and report results and interpretations to project teams and internal governance bodies
• Lead, coordinate, and engage with DMPK colleagues, clinical pharmacologists, and toxicologists in project related activities
• Prepare clear presentations related to the above for internal governance bodies

Qualifications

• Ph.D. in Pharmaceutical Sciences, Pharmacology or a related field
• Minimum of 10 years of industry experience in a biotech or pharmaceutical setting
• Expert in DMPK sciences with knowledge of drug discovery and development processes
• Strong analytical and problem-solving skills
• Experience in DMPK project leadership
• Previous work in the discovery and/or development of CNS drug candidates
• Experience with regulatory submissions including NDAs for small molecules
• Knowledge, experience, and proficiency in supporting GLP-compliant studies
• Good knowledge of all DMPK assays including the use of in silico tools for PK prediction
• Proficiency with Phoenix WinNonlin and other software for NCA and PK modeling in small molecule drug discovery and development
• Demonstrated ability to work cross-functionally and communicate scientific findings clearly and effectively
• Collaborative mindset and operates with a sense of urgency
• Strong, proactive communication skills

Work Location

The Senior Director, DMPK Project Lead role based in the US, with occasional travel.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.

The anticipated wage for this position is $177,000 - $338,800.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

In addition, Lilly offers a comprehensive benefit program to eligible employees,

• eligibility to participate in a company-sponsored 401(k)
• pension
• vacation benefits
• eligibility for medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly