Senior Director, Clinical Science

Jobvite, Inc.; Emeryville (CA); Hybrid; USD 260,000 - 330,000; Full time

Job summary

CytomX Therapeutics, Inc. is seeking a Senior Director, Clinical Science to provide strategic and scientific leadership for oncology programs from early to late-stage development.

You will translate safety, efficacy, pharmacology, and biomarker data into actionable recommendations to guide clinical strategy and study execution. Your role includes leading integrated data reviews, strengthening interpretation, and delivering high-quality scientific outputs for development and regulatory decisions,

Qualifications

• MD, PharmD, PhD, or an equivalent advanced degree in medicine, pharmacy, life sciences, or a related discipline.
• At least 10 years in biotech/pharma with 7+ years in direct clinical development.

Responsibilities

• Provide scientific leadership for design, execution, interpretation of oncology studies (Phase 1–3).
• Develop and review protocols, amendments, investigator materials, CSRs and regulatory content.
• Integrate efficacy, safety, pharmacology, biomarker data to inform clinical strategy.
• Lead ongoing clinical data review in collaboration with cross-functional teams.
• Communicate scientific recommendations on study design, populations, endpoints, dose and schedule.

Skills

Clinical leadership

Strategic thinking

Communication

Cross-functional collaboration

Education

MD/PhD/PharmD or equivalent

Job description

Headquarters Location: Emeryville, CA

Candidate Location: Hybrid

Travel Required: 10%

Reports To: VP, Clinical Development

Department: Clinical Development

Position Type: Full-time, Exempt

About CytomX Therapeutics:

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates(“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com.

Who You Are and What You’ll Do:

You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. As Senior Director, Clinical Science, you will provide strategic and scientific leadership for one or more oncology programs spanning early- through late-stage clinical development. You will collaborate across functions to translate emerging safety, efficacy, pharmacology, biomarker, and operational data into clear recommendations that advance clinical strategy and study execution.

Your immediate priorities will include leading integrated clinical data review for assigned studies, strengthening scientific interpretation and decision-making, supporting high-quality study execution, and preparing clinical-science deliverables for upcoming development and regulatory decisions.

Job Responsibilities:

• Provide scientific leadership for the design, execution, interpretation, and communication of clinical studies across Phase 1 through Phase 3 oncology development programs, based on assigned program needs.
• Lead the development and review of protocols, protocol amendments, investigator materials, clinical study reports, regulatory content, and internal clinical-development materials.
• Integrate efficacy, safety, pharmacokinetic, pharmacodynamic, biomarker, and operational data to identify trends, risks, opportunities, and implications for clinical strategy.
• Lead ongoing clinical data review in collaboration with Clinical Operations, Biostatistics, Data Management, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and other relevant functions.
• Develop and clearly communicate scientifically grounded recommendations regarding study design, patient populations, endpoints, dose and schedule, data analyses, and future development options.
• Serve as a senior Clinical Science representative on study and program teams, facilitating alignment, timely decisions, and clear accountability.
• Anticipate complex clinical-program risks, convene the appropriate stakeholders to evaluate options, and recommend a timely path forward.
• Contribute to clinical-development plans and short‑and long‑range program strategy based on emerging evidence, the evolving treatment landscape, and patient needs.
• Support interactions with investigators, external experts, partners, vendors, and regulatory authorities, as appropriate.
• Communicate complex clinical and scientific information clearly to executive leaders, governance bodies, cross‑functional teams, investigators, and other external audiences.
• Coach and mentor clinical scientists and other colleagues through scientific expertise and cross‑functional leadership, without direct people‑management responsibility.
• Maintain current knowledge of oncology standards of care, emerging scientific evidence, the competitive landscape, and applicable regulatory guidance.
• Perform responsibilities in accordance with applicable regulations, quality standards, company policies, and ethical requirements.

Minimum Qualifications:

• MD, PharmD, PhD, or an equivalent advanced degree in medicine, pharmacy, life sciences, or a related discipline.
• At least 10 years of relevant biotechnology or pharmaceutical industry experience, including at least 7 years of direct clinical‑development experience. An equivalent combination of education and experience may be considered.

Preferred Qualifications:

• Clinical‑development experience in oncology, including meaningful experience with the design, execution, analysis, and interpretation of interventional clinical studies.
• Demonstrated ability to lead complex clinical‑science deliverables and influence multidisciplinary stakeholders in an individual‑contributor capacity.
• Experience integrating clinical safety, efficacy, pharmacology, biomarker, and operational information into scientifically grounded development recommendations.
• Strong knowledge of clinical trial methodology, clinical data review, scientific documentation, and applicable regulatory and quality expectations.
• Experience developing or contributing to protocols, clinical study reports, regulatory documents, or other major clinical‑development deliverables.
• Ability to communicate complex scientific and clinical information clearly, concisely, and persuasively to technical and nontechnical audiences.
• MD or MD/PhD with relevant oncology clinical‑development experience.
• Experience spanning both early‑ and late‑stage oncology clinical development.
• Experience contributing to regulatory interactions, clinical‑development plans, or major regulatory submissions.
• Experience supporting dose optimization, benefit‑risk assessment, and development of clinical data‑review strategies.
• Experience integrating biomarkers, translational findings, or patient‑selection strategies into clinical‑development decisions.
• Experience with antibody‑drug conjugates, T‑cell engagers, immuno‑oncology agents, cytokines, or other complex oncology therapeutic modalities.
• Experience supporting global or multicenter clinical studies.
• Experience presenting clinical data to governance bodies, investigators, regulatory authorities, or external scientific audiences.
• Experience coaching and mentoring clinical‑science colleagues.
• Experience working effectively in a collaborative biotechnology environment with evolving priorities and resource constraints.

How You Will Work:

• Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
• Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
• Exhibits strong interpersonal skills and self‑awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
• Shows continuous improvement and a commitment to self‑management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
• Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
• Contributes to strategy and innovation. Contributes to or leads elevating and actionable strategies. Ideates and creates unique opportunities to advance the organization.
• Demonstrates leadership and a commitment to organizational values. Takes ownership and has a strong sense of personal accountability. Consistently achieves or exceeds goals and expectations. Puts significant emphasis on living / upholding company values.

Compensation, Benefits, and So Much More

• The expected salary range for this role based on the primary location for this position in California is $260,000 - $330,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job‑related factors permitted by law.
• A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
• A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
• A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.

Conditions of Employment

• Background investigations are required for all positions at CytomX, consistent with applicable law.

CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)

CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply.

We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients.

Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.

Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre‑employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship.

If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [e-mail].

Please review our Applicant Personal Information Processing Notice to understand what types of personal information we collect from job applicants and why we process such information.