Senior Director, Analytical Development (CMC) – Small Molecule

Centessa Pharmaceuticals; Boston (MA); On-site; USD 180,000 - 230,000; Full time

Job summary

Centessa Pharmaceuticals seeks a Senior Director of Analytical Development within its CMC group to lead analytical strategies for small molecule drug substances and oral solid dose forms across development stages. The role emphasizes cross-functional leadership, external vendor management, and regulatory support.

The candidate will oversee method development, validation, and transfer at CDMOs, ensuring data integrity for regulatory filings and cGMP compliance, while collaborating with Quality

Qualifications

• PhD in chemistry or pharmaceutical sciences, strongly preferred.
• 10+ years in small molecule pharma with focus on analytical development.
• Experience with GMP validation and managing outsourced analytical activities.

Responsibilities

• Lead analytical strategies for small molecule drug substances and solid oral doses across development stages.
• Direct method development, validation, and transfer at external CDMOs.
• Ensure regulatory filings data quality and compliance with cGMP and global standards.
• Collaborate with Quality and project management to support IND through registration activities.

Skills

Analytical development

Vendor management

Regulatory documentation

Cross-functional leadership

Education

PhD in Chemistry or Pharmaceutical Sciences

Job description

Centessa Pharmaceuticals seeks a Senior Director of Analytical Development within its CMC group to lead analytical strategies for small molecule drug substances and oral solid dose forms across development stages. The role emphasizes cross-functional leadership, external vendor management, and regulatory support.

The candidate will oversee method development, validation, and transfer at CDMOs, ensuring data integrity for regulatory filings and cGMP compliance, while collaborating with Quality