Senior Digital Manufacturing Architect for Cell Therapy

AstraZeneca; California (MD); On-site; USD 127,000 - 191,000; Full time

Job summary

AstraZeneca is seeking an experienced Digital Manufacturing Platform Architect to own the product vision for next-generation cell therapy digital platforms. You will govern LIMS/MES implementations, orchestrate cross‑functional teams, and ensure partner deliveries meet compliance and quality standards.

Responsibilities include defining integration requirements, steering Tulip and automation projects, and leading data‑driven manufacturing initiatives with an emphasis on scale, security, and

Qualifications

• Bachelor's degree in Computer Science, Engineering, Automation Engineering, Information Systems, Electrical Engineering, or related field.
• 8+ years of experience in manufacturing systems, digital manufacturing, MES/LIMS implementation, or automation engineering.
• Strong technical product ownership or program management experience leading complex manufacturing system implementations through internal teams and/or external delivery partners.
• Experience with MES/LIMS platforms in pharmaceutical, biotech, cell therapy, or regulated manufacturing.
• Proven experience managing and governing external vendors, system integrators, or delivery partners — including reviewing technical designs, challenging architectural decisions, and validating implementation quality.
• Experience integrating manufacturing automation systems, robotics, environmental monitoring, and OT systems.
• Hands‑on technical background across API development and integration, Middleware platforms (HighByte, OPC-UA, MQTT), File system management (SMB, NFS) and scripting, Database design and connectivity, Event‑driven architectures.

Responsibilities

• Delivery Partner Governance & Product Ownership: own internal technical product ownership across digital manufacturing workstreams and hold external partners to quality and compliance standards.
• Custom LIMS Applications & Digital Manufacturing Platforms: oversee delivery of LIMS apps and scalable platforms for Cell Therapy operations, defining MES/LIMS requirements and interfaces.
• MES & LIMS Workflow Orchestration: define orchestration frameworks to integrate MES, LIMS, ERP, automation, and data platforms with vendor validation.
• Tulip Manufacturing Applications: own Tulip roadmap, define requirements, user stories, and acceptance criteria; validate reusable components.
• Robotics & Manufacturing Automation Integration: govern integration of robotics, OT systems, and edge devices with vendor design validation.
• Enterprise Systems Integration: define real-time tracking, data models, and API integrations with ERP and supplier apps.
• Technical Leadership & Solution Delivery: manage roadmaps, sprints, CI/CD, DevSecOps, and ensure GxP compliance.
• AI & Advanced Digital Manufacturing: apply AI/ML for optimization, predictive maintenance, and digital twins.
• Cross‑Functional Collaboration & Scale: establish global standards and templates to accelerate scale across sites.

Job description

AstraZeneca is seeking an experienced Digital Manufacturing Platform Architect to own the product vision for next-generation cell therapy digital platforms. You will govern LIMS/MES implementations, orchestrate cross‑functional teams, and ensure partner deliveries meet compliance and quality standards.

Responsibilities include defining integration requirements, steering Tulip and automation projects, and leading data‑driven manufacturing initiatives with an emphasis on scale, security, and