Senior Data Scientist, Biologics Discovery

Scorpion Therapeutics; Spring House (PA); On-site; USD 109,000 - 175,000; Full time

Benefits offered by this job

Medical/dental/vision

Life insurance

Retirement plan/401(k)

Paid time off

Job summary

Scorpion Therapeutics in Spring House, PA seeks a Senior Data Scientist (Biologics Discovery) to design featurization, curate datasets from antibody/protein sequence, construct, assay, and biophysical data, and build trusted ML models.

You will collaborate with ISD and DS/AI teams to ensure reproducible training datasets, establish evaluation frameworks, and champion responsible AI across the DMTL cycle.

Qualifications

• Master’s or Ph.D. in CS/ML/Computational Biology or related field.
• 2+ years applying ML to complex biomedical data.
• Proficiency in Python (PyTorch, scikit-learn) and SQL.
• Experience converting heterogeneous data into robust features.
• Knowledge of leakage and distribution shift risks.
• Ability to collaborate in matrixed R&D.

Responsibilities

• Develop featurization and datasets from sequence, construct, assay, and biophysical data.
• Specify features/labels with data engineers; preserve raw representations.
• Curate, document, and version datasets for reproducibility.
• Collaborate on standardized training datasets and ownership boundaries.
• Partner with discovery scientists to frame ML around decision points.
• Work with ontology and MLOps colleagues to align dataset semantics.
• Champion reproducibility, documentation, and responsible AI.

Skills

Applied ML experience

Dataset curation

Python (PyTorch, scikit-learn)

SQL

Collaboration in matrixed R&D

Education

Master’s or Ph.D. in CS/ML/Computational Biology/Bioinformatics/Statistics

Tools

Python (PyTorch, scikit-learn)

SQL

Cloud training/data infrastructure

Job description

About The Opportunity

Senior Data Scientist (Biologics Discovery) on Data, Data Science & Artificial Intelligence (DDSAI), partnering with In Silico Discovery (ISD) to build data-facing ML capabilities that make ISD molecular models faster and more trustworthy.

Position Summary

Design featurization and dataset curation, build/evaluate applied models on biologics assay, biophysical, and sequence/construct data, and define evaluation frameworks to keep models trustworthy.

Key Responsibilities

• Develop featurization and model-ready datasets from antibody/protein sequence, construct, assay, and biophysical data.
• Specify features/labels/aggregation levels with data engineers; preserve raw representations where needed.
• Curate, document, and version datasets for reproducibility/traceability.
• Collaborate with ISD on standardized, traceable training datasets and DS vs. ISD ownership boundaries.
• Partner with discovery scientists to frame ML around real decision points in the DMTL cycle.
• Work with ontology and MLOps colleagues to align dataset semantics and reliable model deployment.
• Champion reproducibility, documentation, and responsible AI.

Qualifications

Required

• Master’s or Ph.D. in CS/ML/Computational Biology/Bioinformatics/Statistics (or related).
• 2+ years applied ML (development, evaluation, dataset curation) on complex scientific/biomedical data.
• Proficiency in Python (PyTorch, scikit-learn) and SQL.
• Experience converting heterogeneous experimental data into robust features/training sets; exposure to cloud training/data infrastructure.
• Knowledge of evaluation/validation and risks of leakage and distribution shift.
• Ability to collaborate in matrixed R&D.

Preferred

• Biologics/antibody or protein language models.
• Active learning, Bayesian optimization, sequence-based generative models for molecular design.
• Familiarity with biophysical/assay data and developability endpoints.
• MLOps, experiment tracking, model monitoring.
• Ontologies/knowledge graphs for data reuse and AI-ready datasets.

Location/Work

Spring House, PA (strongly preferred), Titusville, NJ, Raritan, NJ, or Madrid, Spain; no remote option.

Compensation & Benefits (explicit)

• Anticipated base pay range: $109,000-$174,800; eligible for annual performance bonus.
• Benefits include medical/dental/vision, life insurance, short-/long-term disability, retirement plan/401(k), and time off (vacation up to 120 hrs/yr; sick up to 40 hrs/yr; holiday/floating holidays up to 13 days/yr; work/personal/family time up to 40 hrs/yr).