Senior Computational Synthetic Chemist: AI-Driven Route Design

Ginkgo Bioworks Inc.; Boston (MA); On-site; USD 115,000 - 165,000; Full time

Benefits offered by this job

Competitive compensation

Public company equity

Comprehensive medical, dental & vision

Job summary

Ginkgo Bioworks in Boston seeks a Senior Engineer I, Computational Synthetic Chemist to design and run multi-step syntheses of drug-like molecules, owning routes end-to-end from design to purification. You will leverage CASP, retrosynthesis, and predictive tools to guide practical chemistry within automated workflows.

You will mentor junior chemists, integrate experimental results with computational planning, and help scale computational workflows into production settings, joining a

Qualifications

• Ph.D. or equivalent with extensive synthetic chemistry experience.
• Ability to design multi-step syntheses, five+ steps, on schedule.
• Independent route-design judgment under real constraints with broad toolkit.
• Hands-on CASP/retrosynthesis with judgment to evaluate reliability.
• Fluency with chemical structure and reaction data, registrations, stereochemistry.

Responsibilities

• Design and execute multi-step syntheses of drug-like molecules.
• Own route selection, execution, purification, and characterization end to end.
• Use CASP, retrosynthesis, and reaction-prediction tools routinely.
• Record campaigns in structured, machine-readable form including data.
• Collaborate with chemists, computational scientists, and software engineers.

Skills

Independent route-design judgment

Fluency with chemical structure data

CASP/reaction-prediction tools

HTE / high-throughput experimentation

Education

Ph.D. in synthetic organic chemistry or medicinal chemistry

MS with 6+ years of relevant experience

BS with 9+ years of relevant experience

Tools

CASP tools

Retrosynthesis tools

Reaction data modeling

RDKit / Python scripting

Job description

Ginkgo Bioworks in Boston seeks a Senior Engineer I, Computational Synthetic Chemist to design and run multi-step syntheses of drug-like molecules, owning routes end-to-end from design to purification. You will leverage CASP, retrosynthesis, and predictive tools to guide practical chemistry within automated workflows.

You will mentor junior chemists, integrate experimental results with computational planning, and help scale computational workflows into production settings, joining a