Senior Computational Research Scientist

St. Jude Children's Research Hospital; Tennessee; On-site; USD 104,000 - 186,160; Full time

Job summary

St. Jude Children's Research Hospital is seeking a Senior Computational Research Scientist in Tennessee. This role involves leading computational research projects to develop new methods and analyze data, requiring a PhD or Master's with relevant experience. The successful candidate will have a strong background in computational chemistry and data analysis, along with expertise in scientific computing languages like R and Python. The position offers a competitive salary range of $104,000 - $186,160 per year.

Qualifications

• PhD with 2+ years of relevant experience or Master's degree with 5+ years.
• Strong background in computational chemistry required.
• Proven performance in computational research techniques.

Responsibilities

• Lead and develop computationally focused scientific research projects.
• Organize, interpret, and report relevant data.
• Draft complex manuscripts with minimal supervision.

Skills

Computational chemistry

Molecular dynamics simulations

Molecular docking

Quantitative structure activity relationship modeling

Chemical informatics

R and Python

High performance computing

Data analysis

Education

Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, or Computer Science

Master's degree or PhD preferred

Tools

Knime

RDKit

ChemProp

Job description

The Senior Computational Research Scientist leads, performs, and develops computational research projects under minimal supervision.

The Department of Chemical Biology and Therapeutics (CBT) is seeking a highly motivated computational chemist interested in using state‑of‑the‑art techniques in computer‑aided drug design, virtual screens, and structure‑guided drug design to discover novel small molecule modulators of targets relevant to pediatric disease. The applicant is expected to work alongside domain experts in the biology of pediatric disease, chemists, and pharmacologists, as well as the various institutional shared resources devoted to translational science, in a collaborative project team environment.

The applicant must have a strong background in computational chemistry, including molecular dynamics simulations, molecular docking, pharmacophore modeling, quantitative structure activity relationship modeling, and chemical informatics. The applicant must also be comfortable using high performance computing resources, and developing, maintaining, and mining chemical and biological databases. Proficiency in scientific computing languages such as R and Python, and open‑source programming tools such as Knime, RDKit, and ChemProp is a plus.

Job Responsibilities

• Lead computationally focused scientific research projects with minimal supervision from their PI. Develop new computational methods.
• Identify, process, organize, interpret, review, and report relevant data.
• Direct data collection.
• Present research to colleagues within and outside the institution; draft a complex manuscript with minimal supervision, as required.
• Regularly train and oversee the work of others in computational research and procedures.
• Perform other duties as assigned to meet the goals and objectives of the department and institution.
• Maintains regular and predictable attendance.

Minimum Education and/or Training

• Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field.
• Master's degree or PhD preferred.

Minimum Experience

• Minimum Requirement: Bachelor's degree and 7+ years of relevant experience.
• Experience Exception: Master's degree and 5+ years of relevant experience (OR) PhD with 2+ years of relevant experience.
• Rough criteria for this position based on publication output: 1-2 first author papers IF > 10 (or equivalent contribution to other research outputs).
• Prior experience in computational research techniques and processes.
• Proven performance in earlier role/comparable role.

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Computational Research Scientist.

St. Jude is an Equal Opportunity Employer