Senior Clinical Trial Manager (Sr. CTM)

Nurix Therapeutics; United States; On-site; USD 182,000 - 194,000; Full time

Job summary

Nurix Therapeutics in Brisbane, CA is seeking a Senior Clinical Trial Manager to oversee regional or multi-trial operations, shape study design input, lead vendor/CRO selection, and act as an escalation point for site issues.

You will mentor junior CTMs/CTAs, manage program budgets, ensure audit readiness, and represent Clinical Operations at the program level. Travel ~25% to support trials.

Qualifications

• 8–10+ years in clinical operations and trial management.
• Willing to travel up to 25% of the time.
• Deep knowledge of FDA/EMA/ICH/GCP guidelines.

Responsibilities

• Oversee operational strategy across multiple trials or a regional program.
• Shape protocol strategy and advise on study design and data collection.
• Lead vendor/CRO selection and negotiate contracts at a strategic level.
• Serve as escalation point for vendor or site issues.
• Own program-level budget forecasting and flag financial risk.
• Mentor junior CTMs/CTAs and provide hands-on guidance.
• Lead audit readiness and coordinate program-level inspections.
• Represent Clinical Operations at program-level and externally.

Skills

Trial management

Vendor management

Mentoring

Budget forecasting

Regulatory knowledge

Cross-functional leadership

Education

BA/BS in biology

Job description

Senior Clinical Trial Manager (Sr CTM)

You’ve run trials well — now run more of them, and help others do the same. You’ll manage a portfolio of trials or a full region, own vendor strategy end-to-end, and become the person other CTMs turn to when something’s stuck.

Position Description

This individual manages clinical regions and/or multiple trials simultaneously, with broad involvement in work central to Nurix’s strategic goals, and plays a key role in developing junior clinical operations staff.

The Opportunity

• Own operational strategy across multiple clinical trials and/or a full geographic region
• Shape protocol strategy and provide senior input on study design and data collection approach
• Lead vendor/CRO selection strategy and own contract negotiation leverage across trials
• Serve as the escalation point for vendor or site issues CTMs can’t resolve on their own
• Own program-level budget forecasting and proactively flag financial risk across the portfolio
• Mentor and develop CTMs and CTAs, providing hands‑on guidance and informal supervision
• Lead audit readiness strategy and serve as the point person across multiple trials during inspections
• Represent Clinical Operations at the program or franchise level, and represent Nurix externally at professional events
• Anticipate risk across the trial portfolio and shape process or strategy to prevent issues before they surface
• Lead cross‑functional strategic initiatives rather than simply participating in them

What You’ll Bring

• S./B.A. in biological sciences with 8-10+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Deep working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
• Proven experience managing global trials or multi‑region programs
• Track record leading vendor/CRO relationships at a strategic, not just operational, level
• Experience mentoring or developing junior CTMs/CTAs
• Strong executive presence and ability to influence without direct authority
• Comfortable operating with minimal oversight and setting direction for others
• Outstanding organizational skills, able to manage a portfolio of trials simultaneously
• Thrives in a fast‑paced, small‑company environment, adjusting priorities as needed

Salary Range: $181,900 – $193.827 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location: Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results‑oriented focus
• Hands‑on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI‑integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader‑based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.