Senior Clinical Trial Manager - Metabolic - U.S.

Worldwide Clinical Trials; Clayton (NC); Remote; USD 112,000 - 222,000; Full time

Job summary

Worldwide Clinical Trials is seeking a Senior Clinical Trial Manager for a remote US role. You will lead clinical site management and monitoring activities across studies, partnering with sponsors, CRAs, and cross-functional teams to drive high-quality outcomes.

Responsibilities include directing site activities, ensuring budget adherence, and maintaining rigorous trial standards. Travel up to 25% is required, and a valid passport is necessary.

Qualifications

• The candidate has a Bachelor’s Degree or Nursing Degree and 2+ years in Clinical Trial Manager or equivalent roles.
• 4+ years as a Clinical Research Associate with metabolic or endocrinology trials.
• Ability to travel up to 25% and hold a valid passport.
• Proven ability to lead, motivate, and support remote teams.

Responsibilities

• Lead clinical research associates and site management teams through full study lifecycle.
• Serve as the primary sponsor-facing contact for monitoring and site activities.
• Build strong partnerships and ensure clear communication during study execution.
• Oversee monitoring deliverables to meet study objectives, quality, and budget.
• Identify out-of-scope activities and communicate impacts and solutions.
• Foster collaboration across cross-functional teams for consistent site management execution.
• Provide leadership and operational oversight to project teams for high-quality conduct.

Skills

Clinical trial management

Remote team leadership

Study monitoring

Cross-functional collaboration

Education

Bachelor’s Degree or Nursing Degree

Job description

Who we are

We’re a global, midsize CRO that pushes boundaries, innovates and invents because the path to a cure for the world’s most persistent diseases is not paved by those who play it safe. It is built by those who take pioneering, creative approaches and implement them with quality and excellence.

We are Worldwide Clinical Trials, and we are a global team of over 3,500+ experts, bright thinkers, dreamers and doers and, together, we are changing the way the world experiences CROs – in the best possible way.

Our mission is to work with passion and purpose every day to improve lives and we are looking for others who value this same pursuit.

Why Worldwide

We believe everyone plays an important role in making a world of difference for patients and their caregivers. From our hands-on, accessible leaders, to our cohesive and supportive teams, we are committed to enabling professionals from all backgrounds and experiences to succeed. We prioritize cultivating a diverse and inclusive environment that continues to promote collaboration and creativity. We are proud to be a workplace where people thrive by being themselves and are inspired to do their best work every day. Join us!

Make an Impact as a Senior Clinical Trial Manager at Worldwide

As a Senior Clinical Trial Manager, you'll play a pivotal role in leading clinical site management activities that help bring innovative therapies to patients who need them most. Your leadership will directly support the successful execution clinical trials, ensuring quality, efficiency, and excellence from study start-up through closeout.

Working closely with sponsors, CRAs, and cross-functional project teams, you'll serve as a key strategic partner responsible for driving clinical monitoring activities and delivering high-quality outcomes. This is an opportunity to make a meaningful impact while guiding teams through complex clinical research programs in a collaborative, patient-focused environment.

At Worldwide, you'll join a values-driven culture where leaders work alongside their teams and where every clinical trial is approached with the care, urgency, and commitment patients deserve.

Where You'll Work

This is a remote role open to candidates based in United States. You will collaborate with global teams across multiple time zones.

Travel up to 25% is required to support study and site management activities.

What You'll Do

• Lead and provide direction to Clinical Research Associates and site management team members throughout the full study lifecycle.
• Serve as the primary Site Management representative for clinical monitoring and site activities across assigned projects.
• Act as a key sponsor-facing contact, building strong partnerships and ensuring effective communication throughout study execution.
• Oversee monitoring deliverables to support study objectives, quality expectations, and budget requirements.
• Identify and manage out-of-scope activities while proactively communicating potential impacts and solutions.
• Drive collaboration across cross-functional teams to ensure consistent execution of clinical site management activities.
• Support high-quality study conduct by providing leadership, guidance, and operational oversight to project teams.

What You'll Bring

• Bachelor’s Degree or Nursing Degree, plus 2+ years of experience as a Clinical Trial Manager, Clinical Operations Leader, Clinical Trial Lead, or equivalent role.
• 4+ years of experience as a Clinical Research Associate.
• Ability to travel up to 25%; valid passport required.
• Required experience supporting Metabolic or Endocrinology clinical trials.
• Demonstrated ability to lead, motivate, and support remote teams.

At Worldwide Clinical Trials, we are committed to fostering an inclusive and equitable workplace by providing transparent compensation.

The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates):
United States of America - $112,000.00 - $222,000.00

The salary range provided is intended to give candidates an understanding of potential earnings. Compensation will fall within the provided range, and it not a guarantee of exact salary. The final salary will be determined based on relevant experience, performance, education, and internal equity. In addition to base salary, we offer a competitive benefits package depending on location. We ensure pay equity and transparency and comply with all applicable labor laws. Salary information will be discussed during the interview process, and we encourage candidates to inquire about compensation at any stage.

We love knowing that someone is going to have a better life because of the work we do.

To view our other roles, check out our careers page at Discover a world of difference at Worldwide ! For more information on Worldwide, visit or connect with us on LinkedIn.