Senior Clinical Trial Manager - Internal Medicine (U.S.)

Worldwide Clinical Trials Holdings, Inc.; North Carolina; Hybrid; USD 112,000 - 222,000; Full time

Job summary

Worldwide Clinical Trials is seeking a Senior Clinical Trial Manager to lead site management and clinical monitoring across multiple projects. The role supports study execution from startup to closeout in a remote, patient-focused environment within the United States.

You will partner with sponsors, CRAs, and cross-functional teams to drive quality and efficiency while traveling up to 25%. The position requires a Bachelor’s or Nursing degree with 2+ years in trial management and 4+ years as a

Qualifications

• Bachelor’s Degree or Nursing Degree plus 2+ years in a Clinical Trial Manager/Operations lead role
• 4+ years of experience as a Clinical Research Associate
• Ability to travel up to 25%; valid passport required
• Experience supporting Internal Medicine trials (IMID, Cardio Metabolic, Rare Disease)
• Demonstrated ability to lead, motivate, and support remote teams

Responsibilities

• Lead and provide direction to Clinical Research Associates and site management teams across the full study lifecycle
• Serve as the primary Site Management representative for clinical monitoring and site activities across assigned projects
• Act as sponsor-facing contact, building partnerships and ensuring effective communication during study execution
• Oversee monitoring deliverables to support study objectives, quality, and budget requirements
• Identify and manage out-of-scope activities while communicating potential impacts and solutions
• Drive collaboration across cross-functional teams to ensure consistent execution of clinical site management activities
• Provide leadership, guidance, and operational oversight to project teams to support high-quality study conduct

Skills

Clinical trial management

Remote team leadership

Travel flexibility

Cross-functional collaboration

Education

Bachelor’s Degree or Nursing Degree

Job description

Join a global Contract Resource Organization (CRO) where innovation meets purpose. At Worldwide Clinical Trials, we're driven by a shared commitment to improving lives through high-quality clinical research. Our teams are empowered to think creatively, take ownership, and deliver meaningful work that helps bring life-changing therapies to patients around the world. With more than 4,000 professionals across the globe, we foster a collaborative and inclusive environment where diverse perspectives are valued, growth is encouraged, and every contribution makes an impact. Whether you're building your career or bringing years of experience, you'll have the opportunity to learn, grow, and help shape the future of clinical research.

Make an Impact as a Senior Clinical Trial Manager at Worldwide

As a Senior Clinical Trial Manager, you'll play a pivotal role in leading clinical site management activities that help bring innovative therapies to patients who need them most. Your leadership will directly support the successful execution of clinical trials, ensuring quality, efficiency, and excellence from study start-up through closeout. Working closely with sponsors, CRAs, and cross-functional project teams, you'll serve as a key strategic partner responsible for driving clinical monitoring activities and delivering high-quality outcomes. This is an opportunity to make a meaningful impact while guiding teams through complex clinical research programs in a collaborative, patient-focused environment. At Worldwide, you'll join a values-driven culture where leaders work alongside their teams and where every clinical trial is approached with the care, urgency, and commitment patients deserve.

Where You'll Work

This is a remote role open to candidates based in United States. You will collaborate with global teams across multiple time zones. Travel up to 25% is required to support study and site management activities.

What You'll Do

• Lead and provide direction to Clinical Research Associates and site management team members throughout the full study lifecycle.
• Serve as the primary Site Management representative for clinical monitoring and site activities across assigned projects.
• Act as a key sponsor-facing contact, building strong partnerships and ensuring effective communication throughout study execution.
• Oversee monitoring deliverables to support study objectives, quality expectations, and budget requirements.
• Identify and manage out-of-scope activities while proactively communicating potential impacts and solutions.
• Drive collaboration across cross-functional teams to ensure consistent execution of clinical site management activities.
• Support high-quality study conduct by providing leadership, guidance, and operational oversight to project teams.

What You'll Bring

• Bachelor’s Degree or Nursing Degree, plus 2+ years of experience as a Clinical Trial Manager, Clinical Operations Leader, Clinical Trial Lead, or equivalent role.
• 4+ years of experience as a Clinical Research Associate.
• Ability to travel up to 25%; valid passport required.
• Required experience supporting Internal Medicine clinical trials (IMID, Cardio Metabolic, Rare Disease).
• Demonstrated ability to lead, motivate, and support remote teams.

Discover the Difference at Worldwide Clinical Trials

We love knowing that someone is going to have a better life because of the work we do.

Salary range

At Worldwide Clinical Trials, we are committed to fostering an inclusive and equitable workplace by providing transparent compensation. The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates): United States of America - $112,000.00 - $222,000.00 The salary range provided is intended to give candidates an understanding of potential earnings. Compensation will fall within the provided range, and it not a guarantee of exact salary. The final salary will be determined based on relevant experience, performance, education, and internal equity. In addition to base salary, we offer a competitive benefits package depending on location. We ensure pay equity and transparency and comply with all applicable labor laws. Salary information will be discussed during the interview process, and we encourage candidates to inquire about compensation at any stage.

Equal Opportunity Employer

Worldwide is an equal opportunity employer that is committed to enabling professionals from all backgrounds and experiences to succeed and, to that end, we prioritize attracting diverse talent and cultivating an inclusive environment that encourages collaboration and creativity. We know that when our employees feel appreciated and included, they can be more creative, innovative, and successful. We’re on a mission to hire the very best and are committed to creating exceptional employee experiences where everyone is respected and has access to equal opportunity. We provide equal employment opportunities to all employees and applicants regardless of race, color, ethnicity, ancestry, religion, national origin, gender, sex, gender identity or expression, sexual orientation, age, citizenship, marital or parental status, disability, military status, or other class protected by applicable law.

This is who we are. We’re a team of clinicians, scientists, and researchers who want to make healthcare better. We were founded on an unwavering commitment to authentic, personalized attention. And today, as CROs consolidate and the industry changes rapidly, that personalized attention is more important than ever. We all came to this industry for different reasons, from different walks of life. If you ask any one of us why we’re here, you’ll get a different answer. And that’s what makes us special.