Senior Clinical Trial Manager

ICON Clinical Research; Center Square (PA); Remote; USD 120,000 - 180,000; Full time

Benefits offered by this job

Annual leave entitlements

Health insurance options

Retirement planning offerings

LifeWorks EAP

Life assurance

Flexible country-specific benefits

Job summary

ICON plc is seeking a Senior Clinical Trial Manager for a remote US role. You will oversee operational delivery from start-up to closeout, ensuring quality, timelines, and budgets while working with sponsors, investigators, vendors, and cross-functional teams.

You will lead study start-up, enrollment strategies, and oversight of monitoring, risk mitigation, and reporting, while mentoring CRAs and ensuring compliance with ICH-GCP and regulatory requirements.

Qualifications

• Bachelor's degree in Life Sciences or related field or equivalent experience.
• Significant Clinical Trial Management experience in CRO/pharma/biotech.
• Lead and deliver studies from start-up to closeout.
• Strong ICH-GCP understanding and regulatory knowledge.
• Experience managing timelines, budgets, vendors, and stakeholders.
• Ability to identify risks and drive study execution.
• Monitoring experience preferred.
• Global/complex trials experience preferred.
• Willingness to travel up to 20%.

Responsibilities

• Oversee the operational delivery of trials, ensuring milestones, timelines, budgets, and quality.
• Drive start-up activities, site activation, enrollment strategies, and execution through database lock.
• Provide oversight of progress, monitoring metrics, and site performance.
• Develop oversight plans, monitoring strategies, and risk mitigation.
• Identify operational challenges and implement solutions for successful delivery.
• Build relationships with sponsors, investigators, vendors, and stakeholders.
• Review performance metrics and provide status updates and reports.
• Mentor and collaborate with CRAs and study team members.
• Ensure activities comply with protocol, ICH-GCP, and regulatory requirements.

Skills

Clinical Trial Mgmt

ICH-GCP

Budget Mgmt

Vendor Mgmt

Cross-functional

Study Start-up

Monitoring

Global Trials

Travel

Education

Life Sciences degree

Equivalent experience

Job description

Senior Clinical Trial Manager - Remote, US

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

Senior Clinical Trial Manager

We are currently seeking a Senior Clinical Trial Manager to join our diverse and dynamic team at ICON. In this critical leadership role, you will oversee the operational delivery of clinical trials from study start-up through closeout, ensuring quality, compliance, and execution against study timelines and objectives.

As the clinical operations lead, you will work cross-functionally with sponsors, investigators, vendors, and internal stakeholders to drive successful study outcomes while identifying and mitigating risks throughout the trial lifecycle.

What you will be doing

• Lead the operational delivery of assigned clinical trials, ensuring milestones, timelines, budget expectations, and quality standards are achieved.
• Drive study start-up activities, site activation, enrollment strategies, and study execution through database lock.
• Provide oversight of study progress, monitoring activities, clinical metrics, and site performance.
• Develop and implement effective study oversight plans, monitoring strategies, and risk mitigation approaches.
• Identify operational challenges and proactively implement solutions to ensure successful study delivery.
• Build and maintain strong relationships with sponsors, investigators, vendors, and cross-functional stakeholders.
• Review study performance metrics and provide regular status updates and reporting.
• Support, mentor, and collaborate with Clinical Research Associates (CRAs) and other study team members.
• Ensure all clinical trial activities comply with protocol requirements, ICH-GCP guidelines, and applicable regulatory requirements.

Your Profile

• Bachelor's degree in Life Sciences, Health Sciences, Nursing, Pharmacy, or another relevant scientific discipline, or an equivalent combination of education and experience.
• Significant Clinical Trial Management experience within a CRO (preferred), pharmaceutical, or biotechnology environment.
• Demonstrated ability to successfully lead and deliver clinical studies from start-up through closeout.
• Strong understanding of clinical trial operations, ICH-GCP, and applicable regulatory requirements.
• Experience managing study timelines, budgets, vendors, and cross-functional stakeholders.
• Proven ability to identify risks, solve complex operational challenges, and drive study execution.
• Prior monitoring experience preferred.
• Experience managing global and/or complex clinical trials preferred.
• Ability to travel up to 20%.

#LI-MN1

#LI-Remote

What ICON can offer you

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well‑being.
• Life assurance
• Flexible country‑specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site (https://careers.iconplc.com/benefits) to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here (https://careers.iconplc.com/reasonable-accommodations)

Visit our careers site (https://careers.iconplc.com/benefits) to read more about the benefits ICON offers.