Senior Clinical Pharmacology & PK Lead — Remote/Hybrid

Disc Medicine; Watertown (MA); Hybrid; USD 247,000 - 297,000; Full time

Benefits offered by this job

Flexible work environment

Hybrid role

Job summary

Disc Medicine in Watertown, MA, offers a hybrid opportunity for a Clinical Pharmacology Lead to guide multiple programs. You will design, execute, analyze and interpret clinical pharmacology studies including first‑in‑human, DDI, biopharmaceutics and ADME, partnering with internal teams, CROs and vendors to ensure scientific rigor and budget adherence.

You will also represent clinical pharmacology in regulatory interactions, contributing to regulatory strategy and submissions while mentoring

Qualifications

• PhD in clinical pharmacology, pharmaceutical sciences or related areas such as pharmacokinetics, pharmacology or drug metabolism.
• Experience in conducting clinical pharmacology studies including study design, PKPD data analysis and/or population PK analysis, and result interpretation.
• Experience with regulatory guidance and IND/EA submissions is preferred.

Responsibilities

• Serve as a clinical pharmacology lead for multiple programs and collaborate with cross‑functional teams.
• Manage and execute clinical pharmacology deliverables with CROs and internal partners.
• Design, execute, analyze, interpret and report clinical pharmacology studies (FIH, DDI, biopharmaceutics, ADME).
• Develop and maintain relationships with clinical operations, development, toxicology, DMPK, biostatistics and regulatory teams.
• Represent clinical pharmacology in regulatory interactions and contribute to regulatory strategy.

Skills

Clinical pharmacology

PK/PD analysis

Population PK

Regulatory interactions

CRO management

Bioanalytical collaboration

WinNonlin/R/NONMEM

Education

PhD in clinical pharmacology or related

Tools

WinNonlin

R

NONMEM

Monolix

Job description

Disc Medicine in Watertown, MA, offers a hybrid opportunity for a Clinical Pharmacology Lead to guide multiple programs. You will design, execute, analyze and interpret clinical pharmacology studies including first‑in‑human, DDI, biopharmaceutics and ADME, partnering with internal teams, CROs and vendors to ensure scientific rigor and budget adherence.

You will also represent clinical pharmacology in regulatory interactions, contributing to regulatory strategy and submissions while mentoring