Senior Chemist

Programmable Medicine; Redwood City (CA); On-site; USD 95,000 - 128,000; Full time

Benefits offered by this job

Comprehensive medical, dental, and vision benefits

Stock options

Annual bonus participation

Job summary

Programmable Medicine, located in Redwood City, is seeking a Senior Chemist for analytical method development to advance precision medicines targeting inflammation. You will join a dynamic team, contributing to innovative drug development with a rich benefits package, including medical, dental, vision, and stock options.

The ideal candidate has a BS degree in Chemistry and at least 5 years in the pharmaceutical industry, with expertise in stability studies and various analytical techniques.

Qualifications

• Minimum of 5 years of pharmaceutical industry experience required.
• In-depth expertise with analytical method development and validation.
• Experience with injectable and oral dosage forms.

Responsibilities

• Manage stability study and trend analysis for drug substances/products.
• Develop and validate analytical methods.
• Test drug samples and maintain instruments in the lab.

Skills

Stability study expertise

Analytical method development

Problem-solving skills

Communication skills

Education

BS degree in Chemistry or related area

Tools

HPLC

UPLC

LC-MS

ICP-MS

Job description

Overview

Programmable Medicine, a clinical stage biopharmaceutical company located in Redwood City, is seeking a motivated Senior Chemist Analytical Method Development. We are focused on developing novel nanomedicines, HD therapeutics (HDTs), to treat unmet medical needs in ophthalmology, neurology, inflammatory diseases, and neuro-oncology. Our HD platform builds therapeutics that are selectively taken up only by inflamed tissues, allowing us to treat diseases with unprecedented precision.

This position reports to the Director, Analytical Research and Development and will manage develop analytical methods and test various drug substances and drug products to support Medicinal Chemistry, Translational, Manufacturing, and CDMOs. The successful candidate will be part of a dynamic, interdisciplinary team and require a high degree of creativity and initiative. This is an exciting opportunity to help drive the development of novel therapies for unmet medical needs in multiple indications.

The Position

The Chemist / Senior Chemist Analytical Method Development will serve as a key member of our development team, working on-site full-time, in our Redwood City laboratory, focusing on novel early and late-phase programs.

Responsibilities

• Manage stability study and trend analysis such as design/review stability studies, prepare/review protocols, and monitor ongoing stability studies in-house and at various CDMOs
• Develop various analytical methods.
• Test various drug substance/drug product samples.
• Manage, set up, and maintain all instruments in the analytical lab.
• Keep and accurately maintain detailed electronic laboratory notebooks.
• Perform tasks per protocols as required.
• Additional responsibilities may be added as required.

Job Requirements

• BS degree in Chemistry, Analytical Chemistry, or closely related scientific area is required along with a minimum of 5 years of pharmaceutical industry experience.
• In-depth expertise with stability study, analytical method development and validation with HPLC, UPLC.
• Expertise in HPLC, HPLC/UPLC, LC-MS, SEC, and ICP-MS analytical techniques is preferred.
• Prior experience with analytical method development and validation for small molecule drugs.
• Experience with analytical method development and various tests for polymer-drug conjugates and/or biologics drug candidates are preferred.
• Experience with injectable and oral dosage forms
• Independent, problem-solving, and troubleshooting skills.
• Knowledge of GLP & GMP requirements
• Well organized and self-directed
• Ability to communicate scientific findings and recommendations in one-on-one discussions, departmental meetings, and prepare reports.
• Ability to work in a fast-paced, dynamic environment with multiple projects and priorities.

Must be able to work on site at our Redwood City facility, five days per week.

About Programmable Medicine

This is a unique opportunity to join a team focused on the development of a new class of precision medicines that selectively treat diseased cells in regions of inflammation. By making precision medicine even more precise, our nanomedicine technology has the potential to change the standard of care across ophthalmology, neurology, inflammatory diseases and neuro-oncology. You will have the opportunity to learn new skills and gain a better understanding of cutting-edge technology.

We have a comprehensive compensation package including fully paid medical, dental and vision benefits for you and your family. We want our employees to become shareholders and offer new hire stock options. The company also offers participation in the annual bonus program. The salary range for MS candidates located in the Bay Area, with a minimum of 8 years of industry experience is $95,000 - $128,000, depending on years of experience and relevant skill sets.