Senior Biostatistician II

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 132,200 - 198,200; Full time

Job summary

Vertex Pharmaceuticals Incorporated is looking for a Senior Biostatistician II to perform statistical analyses supporting Global Medicines Development. This hybrid-eligible role requires strong skills in SAS, R, and statistical methods applicable to drug development.

The successful candidate will have a Ph.D. or Master's degree in Statistics/Biostatistics and typically 3 years of related experience, collaborating effectively in a team environment to contribute to clinical trial design, data analysis, and reporting.

Qualifications

• Ph.D. or master's degree required.
• 3 years of experience desired for master's degree holders.

Responsibilities

• Design and execute technical/statistical infrastructure for clinical trials.
• Author study Statistical Analysis Plans (SAPs).
• Conduct Cross-functional Data Review meetings.
• Collaborate with statistical programming for TFL delivery.
• Develop statistical sections of protocols.
• Contribute to clinical study reports.

Skills

SAS

R statistical software

Statistical methods in drug development

Critical thinking

Verbal communication

Collaboration

Education

Ph.D. or Master's degree in Statistics or Biostatistics

Job description

Overview

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset.

Key Duties and Responsibilities

• Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities.
• Participates in regular Study Execution Team (SET) team meetings as the functional representative.
• Works under supervision to author study Statistical Analysis Plans (SAPs), including table, figure, and listing (TFL) shells, and presentation to Statistical Review Forum (SRF).
• Plans and conducts Cross‑functional Data Review (xFDR), Key Results Memo (KRM), and Data Dissemination Plan (DDP) to facilitate the review, summary, and dissemination of key study data/results.
• Collaborates with statistical programming and other functions to ensure timely delivery of TFLs with good quality; provides input into programming specifications and review.
• Develops statistical section of protocols, including sample size estimates and randomization plan.
• Contributes to clinical study reports (CSRs) and related processes; may author or co‑author methodological or study‑related publications and posters.
• Implements design and analysis methods at the study level and participates in SRF discussions of studies assigned to others.
• Contributes to departmental working group efforts on various technical and operational issues.
• Seeks guidance and mentoring on new and complex issues.
• Completes assigned work in a resourceful manner and creates alternative approaches to achieve desired results if needed.
• Develops a basic knowledge of related disciplines with a drug developer mindset.

Knowledge and Skills

• Competence with SAS and R statistical software.
• Demonstrated understanding of statistical methods used in drug development.
• Ability to show critical thinking with logical problem‑solving.
• Excellent written and verbal communication skills.
• Excels in a team environment.
• Collaborates well with non‑statisticians.

Education and Experience

• Ph. D. or master's degree in Statistics or Biostatistics.
• Typically requires 3 years of experience for those with a master's degree or the equivalent combination of education and experience.

Pay Range

$132,200 - $198,200

Flex Designation

Hybrid‑Eligible Or On‑Site Eligible

Flex Eligibility Status

In this Hybrid‑Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On‑Site: work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Equal Employment Opportunity Statement

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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