Senior Biostatistician - AI-Driven Trial Statistics Lead

Hill Research; Princeton (NJ); On-site; USD 140,000 - 210,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

Job summary

Hill Research in Princeton or Boston is seeking a senior biostatistician who owns the statistical thinking end-to-end for Phase I–III trials, writing SAPs, specifications, and TLF outputs, and validating AI-generated analyses before submission.

You will collaborate with AI/engineers to integrate SDTM/ADaM, design trials, estimands, handling missing data, and regulatory expectations, while maintaining high autonomy and rigorous scientific judgment.

Qualifications

• Hands-on clinical development experience as a trial statistician with independence to reason through design, endpoints, estimands, methods, missing data, and interpretation.
• Authorship of major statistical deliverables (SAPs, analysis specifications, TLF shells, and core documentation).
• Comfort with AI-assisted development tools and skepticism toward code or outputs without validation.

Responsibilities

• Author SAPs and trial deliverables for Phase I–III trials and ensure traceability from protocol to final outputs.
• Own design decisions on endpoints, estimands, analysis methods, and missing data with regulatory alignment.
• Review AI-generated analyses and code for statistical sense and correctness before release.
• Write/modify SAS or R code using AI-assisted tools to produce valid analyses.
• Collaborate daily with AI/engineers, translating statistical intent into product behavior for TriClick™.

Skills

SAS coding

R coding

AI-assisted development

Regulatory knowledge

Data wrangling

Education

PhD or MSc in Biostatistics or related quantitative field

Tools

SAS

R

CDISC ADaM

SDTM

Job description

Hill Research in Princeton or Boston is seeking a senior biostatistician who owns the statistical thinking end-to-end for Phase I–III trials, writing SAPs, specifications, and TLF outputs, and validating AI-generated analyses before submission.

You will collaborate with AI/engineers to integrate SDTM/ADaM, design trials, estimands, handling missing data, and regulatory expectations, while maintaining high autonomy and rigorous scientific judgment.