Senior Bioinformatics Software Engineer — AI-Driven & Cloud

Guardant Health, Inc.; Palo Alto (CA); Hybrid; USD 150,000 - 206,000; Full time

Job summary

Guardant Health, Inc. seeks a Senior Software Engineer, Bioinformatics to design, develop, and maintain scalable software for bioinformatics, life sciences, and clinical diagnostics.

The role combines full-stack skills with AI-assisted practices to support complex scientific workflows in a fast-paced, distributed team environment. The candidate will build robust services with Python, Django/FastAPI, React, and PostgreSQL, deploy on AWS, and contribute to testing, documentation, and CI/CD

Qualifications

• 5+ years of professional software development experience, with significant hands-on development experience using Python.
• Strong experience developing production applications using Python web frameworks such as Django, FastAPI, or similar technologies.
• Experience developing modern web applications using React, JavaScript/TypeScript, HTML, and CSS.
• Strong experience with relational databases, particularly PostgreSQL, including schema design, queries, performance optimization, and data integrity.
• Hands-on experience developing, deploying, and supporting applications in AWS.
• Strong understanding of RESTful APIs, distributed systems, service-oriented architectures, and modern application design principles.
• Experience with automated testing, source control, code review, CI/CD, and modern DevOps practices.
• Demonstrated experience using AI-enabled software engineering tools for activities such as coding, testing, debugging, code review, and documentation.
• Strong problem-solving and analytical skills with the ability to work on complex technical problems with limited supervision.
• Excellent written and verbal communication skills.
• Ability to thrive in a fast-paced, evolving environment and effectively manage multiple priorities.
• Demonstrated ability to collaborate successfully with geographically distributed and cross-functional teams.

Responsibilities

• Design, develop, test, deploy, and maintain robust software applications and services supporting bioinformatics and clinical workflows.
• Build scalable backend services and APIs using Python and modern web frameworks such as Django and FastAPI.
• Develop responsive and maintainable user interfaces using modern frontend technologies such as React.
• Design and optimize relational data models and database solutions using PostgreSQL.
• Architect, deploy, and operate applications and services in AWS environments.
• Apply sound software engineering practices including automated testing, code reviews, CI/CD, observability, security, and infrastructure automation.
• Partner with bioinformatics scientists, computational biologists, product managers, quality teams, and other stakeholders to translate scientific and business requirements into reliable software solutions.
• Develop software capable of supporting complex scientific datasets, analytical workflows, and computational pipelines.

Skills

Python proficiency

Web frameworks

React

PostgreSQL

AWS

RESTful APIs

CI/CD

AI-enabled tools

Education

Bachelor’s degree in CS/Software Engineering/Bioinformatics

Tools

Django

FastAPI

React

Terraform

Docker

Kubernetes

Job description

Guardant Health, Inc. seeks a Senior Software Engineer, Bioinformatics to design, develop, and maintain scalable software for bioinformatics, life sciences, and clinical diagnostics.

The role combines full-stack skills with AI-assisted practices to support complex scientific workflows in a fast-paced, distributed team environment. The candidate will build robust services with Python, Django/FastAPI, React, and PostgreSQL, deploy on AWS, and contribute to testing, documentation, and CI/CD