Senior Bioinformatics Scientist

Natera; Oregon; Hybrid; USD 117,000 - 147,000; Full time

Benefits offered by this job

Medical, dental, vision, life and disb

Free testing for employees and their 


401k and commuter benefits

Employee referral program

Job summary

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics team dedicated to early cancer detection. You will design and implement innovative computational solutions, developing algorithms and pipelines for large-scale genomic datasets to advance early-stage cancer diagnostics.

The ideal candidate holds a PhD in a quantitative field and 0–3 years of experience in bioinformatics, with strengths in Python, NGS analysis, and scalable workflow development in AWS environments.

Qualifications

• PhD required in a quantitative field (Bioinformatics/CS/Statistics/Cancer Biology).
• 0–3 years of bioinformatics or computational biology experience.

Responsibilities

• Innovate, design, and validate advanced algorithms and models for large genomic datasets.
• Co-architect and deploy automated analysis workflows for clinical diagnostics (variant calling, fusion detection, QC).
• Contribute to code reviews, documentation, and optimization of computational infrastructure.
• Analyze multi-omic data with high-performance pipelines in collaboration with wet-lab scientists and statisticians.

Skills

Communication

NGS analysis

Bioinformatics

Python

Workflow orchestration (WDL)

AWS

Linux

Genomic biomarkers

Education

Ph.D. in Bioinformatics / CS / Statistics / Cancer Biology

Tools

WDL

AWS

Job description

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics team dedicated to early cancer detection. As a core member of the Research and Development department, you will play a pivotal role in designing and implementing innovative computational solutions. The ideal candidate possesses a robust background in algorithm development, high-throughput biological data analysis, and scalable pipeline architecture. We are looking for a versatile professional capable of thriving as an individual contributor, a collaborative co-developer, and a key participant in large-scale, cross-departmental initiatives. In this role, you will develop novel algorithms and pipelines while analyzing complex genomic datasets to advance the frontiers of early-stage cancer diagnostics.

PRIMARY RESPONSIBILITIES

• Innovate, design, develop, and validate advanced algorithms and statistical models to extract actionable insights from large-scale genomic datasets for early cancer detection.
• Co-architect, implement, and deploy automated analysis workflows for clinical diagnostics, ensuring robust performance for variant calling, fusion detection, and automated quality control.
• Contribute to rigorous code reviews, maintain comprehensive technical documentation, and drive the continuous optimization of core computational infrastructure.
• Analyze complex multi-omic data using high-performance internal pipelines, collaborating closely with wet-lab scientists and statisticians to meet critical research milestones.

QUALIFICATIONS

• Ph.D. in Bioinformatics, Computer Science, Statistics, Cancer Biology, or a related quantitative field.
• 0-3 years of professional or postgraduate experience in bioinformatics or computational biology.

KNOWLEDGE, SKILLS AND ABILITIES

• Excellent communication skills with a demonstrated ability to present complex computational findings to diverse cross-functional stakeholders.
• Deep expertise in high-throughput DNA sequencing (NGS) analysis, including sequence alignment, mapping, and clinical-grade variant calling.
• A proven track record of developing state-of-the-art, high-impact bioinformatics methodologies.
• Advanced knowledge of data structures, algorithm design, and computational complexity analysis.
• High proficiency in Python and its scientific ecosystem (NumPy, Pandas, Scikit-learn) for data manipulation and automation.
• Experience with workflow orchestration languages (WDL preferred) for building and versioning scalable bioinformatics pipelines.
• Experience with cloud-based distributed computing environments, specifically AWS.
• Familiarity with contemporary analytical techniques and biomarkers in cancer biology.
• Working knowledge of public genomic databases such as TCGA, COSMIC, or OncoKB.
• Proficiency in Linux environments, including command-line tools and shell scripting.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA$117,400—$146,800 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

Competitive Benefits

• Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
• We also offer a generous employee referral program!

If you are based in California, we encourage you to read this important information for California residents.

Natera is proud to be an Equal Opportunity Employer.

We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives.

Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status.

We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.